{"id":"W2887505821","doi":"10.3389/fphar.2018.00880","title":"Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies","year":2018,"lang":"en","type":"review","venue":"Frontiers in Pharmacology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Sodium channel; Ion channel; Tetrodotoxin; Potassium channel; Sodium; Biophysics; Computational biology; Chemistry; Toxin; Saxitoxin; Sodium channel blocker; Nanotechnology; Biology; Biochemistry; Materials science; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002720231,0.0002977228,0.0007111385,0.0001548136,0.0001129521,0.000006415138,0.0002932076,0.0003918365,0.00001324383],"category_scores_gemma":[0.0001271483,0.0002097089,0.0002822638,0.000198019,0.0002707029,0.000004303112,0.0001903524,0.0002725322,0.000001440259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009468039,"about_ca_system_score_gemma":0.0001347943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001565197,"about_ca_topic_score_gemma":0.00000264287,"domain_scores_codex":[0.9983207,0.0003445727,0.0004983601,0.0004220609,0.0001303202,0.0002839813],"domain_scores_gemma":[0.9991776,0.00003269031,0.000441065,0.0002082424,0.0001013974,0.00003895393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00199597,0.0003170875,0.00265056,0.01715687,0.005288751,0.00003613967,0.001440122,0.0004439043,0.005283184,0.0000719453,0.4986517,0.4666638],"study_design_scores_gemma":[0.0009775192,0.0005618302,0.00007945255,0.001226284,0.0005527755,0.00004832425,0.0003330193,0.0008762625,0.01096448,0.00007309486,0.983872,0.0004349652],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008447104,0.9741996,0.00007313682,0.00007543209,0.01631114,0.0006714778,0.00005061659,0.00001124785,0.0001602381],"genre_scores_gemma":[0.01331934,0.9824359,0.0001618392,0.0002177977,0.003054323,0.00007714206,0.0001517817,0.00004833661,0.0005335711],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.4852203,"threshold_uncertainty_score":0.8551683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04215849616651435,"score_gpt":0.3464200166486016,"score_spread":0.3042615204820872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}