{"id":"W2887514374","doi":"10.1534/g3.118.200374","title":"Acute Effects of Drugs on <i>Caenorhabditis elegans</i> Movement Reveal Complex Responses and Plasticity","year":2018,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Drug; Pharmacology; Biology; Caenorhabditis elegans; Neuroscience; Paralysis; Neurotransmitter; Hormesis; Medicine; Central nervous system; Endocrinology; Oxidative stress","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001636123,0.0003966418,0.0003869761,0.0001096815,0.000202413,0.00004219034,0.0003788318,0.0002205571,0.00002466327],"category_scores_gemma":[0.00001766022,0.0004066037,0.0001135475,0.0001186746,0.0005079467,0.000003611605,0.000343757,0.0001037892,0.00001992742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002485626,"about_ca_system_score_gemma":0.0001030196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001772339,"about_ca_topic_score_gemma":0.00003755909,"domain_scores_codex":[0.9978942,0.00014359,0.0004357196,0.000674531,0.0003360564,0.0005159173],"domain_scores_gemma":[0.9986575,0.0000677611,0.0002069731,0.0006353733,0.000224988,0.000207435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002486891,0.000121714,0.00251999,0.0001205628,0.0002217206,0.000006824522,0.0006652439,0.0001244137,0.9336421,0.00004845984,0.001454688,0.06082563],"study_design_scores_gemma":[0.001031383,0.002835217,0.008595701,0.00002636647,0.0001586223,0.00001578274,0.0000738979,0.0001655915,0.9318784,0.0001992608,0.05456811,0.0004516083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9602787,0.03490226,0.00330957,0.0001199869,0.0003676585,0.00048327,0.000165374,0.00002440027,0.00034876],"genre_scores_gemma":[0.965596,0.02561615,0.005711018,0.001377507,0.0006878641,0.00002298243,0.000079717,0.00007148193,0.0008373179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06037402,"threshold_uncertainty_score":0.9998386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008613599341880543,"score_gpt":0.2388133164081419,"score_spread":0.2301997170662614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}