{"id":"W2887561950","doi":"10.1158/1538-7445.am2018-ct124","title":"Abstract CT124: A phase Ib/II study of BMS-813160, a CC chemokine receptor (CCR) 2/5 dual antagonist, in combination with chemotherapy or nivolumab in patients (pts) with advanced pancreatic or colorectal cancer","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Medicine; CCR2; Tumor microenvironment; Pancreatic cancer; CC chemokine receptors; Chemokine receptor; Cancer research; Myeloid; Immunology; Cancer; Internal medicine; Chemokine; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001089658,0.00225561,0.002298269,0.0006389904,0.0004546218,0.001408605,0.001273475,0.001670962,0.005972931],"category_scores_gemma":[0.000598967,0.0007491434,0.00143466,0.0006092085,0.001143173,0.0009629113,0.0003739065,0.003510369,0.001862995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00113108,"about_ca_system_score_gemma":0.001878595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001592178,"about_ca_topic_score_gemma":0.004278789,"domain_scores_codex":[0.9996809,0.0001280242,0.00001885807,0.00005796096,0.00004021203,0.00007420131],"domain_scores_gemma":[0.9996451,0.00002630291,0.00005550882,0.00002652362,0.00002743801,0.0002190673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6188943,0.09499943,0.004864116,0.003041652,0.002649372,0.0006300259,0.0004166097,0.004390145,0.1392454,0.0008210295,0.01084478,0.1192032],"study_design_scores_gemma":[0.4777945,0.5029625,0.006346361,0.00007808122,0.0008005359,0.0003707245,0.00007599193,0.001276603,0.005449753,0.0001857094,0.004609416,0.00004986877],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803289,0.006135536,0.0009298802,0.0009086728,0.000353066,0.004812949,0.002281826,0.0002243625,0.004024839],"genre_scores_gemma":[0.9769759,0.005115899,0.00190975,0.001481573,0.0003050643,0.003768641,0.003702828,0.00004925851,0.00669123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005972931,"threshold_uncertainty_score":0.01998144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02962679274553683,"score_gpt":0.3657353482256614,"score_spread":0.3361085554801246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}