{"id":"W2887634491","doi":"10.1097/mot.0000000000000566","title":"Taking regulatory T-cell therapy one step further","year":2018,"lang":"en","type":"review","venue":"Current Opinion in Organ Transplantation","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Chimeric antigen receptor; Cell therapy; Alloimmunity; Immunology; Homing (biology); Autoimmunity; Genetic enhancement; Antigen; In vivo; Ex vivo; Adoptive cell transfer; T cell; Biology; Medicine; Cancer research; Stem cell; Immune system; Cell biology; Gene; Biotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008352363,0.0009352575,0.001168107,0.001169622,0.0002816963,0.001266542,0.0008528059,0.001832555,0.006098556],"category_scores_gemma":[0.000937153,0.0001797268,0.0005574017,0.0008937169,0.0006789908,0.001889258,0.0008204312,0.003110207,0.003801981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006462901,"about_ca_system_score_gemma":0.001346421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004394431,"about_ca_topic_score_gemma":0.0006431818,"domain_scores_codex":[0.9997106,0.00006192597,0.0000346962,0.00005432833,0.0001044619,0.0000338774],"domain_scores_gemma":[0.9995444,0.0002072734,0.00005228641,0.00001673368,0.0001235146,0.00005562017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009111825,0.00007398768,0.0001152081,0.01687415,0.00007589205,0.0002871614,0.00008432913,0.0003055009,0.003106174,0.008553272,0.09665252,0.8737807],"study_design_scores_gemma":[0.0000171493,0.00005332984,0.0001501105,0.002243715,0.00004250613,0.0006494504,0.00003914232,0.00005955953,0.0004861267,0.002244461,0.9940038,0.00001066601],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001138226,0.9927797,0.0003523059,0.002292978,0.002549114,0.00001098881,0.00001861896,0.00002224249,0.001860261],"genre_scores_gemma":[0.00127154,0.9914417,0.0004412868,0.002658777,0.002012426,0.00002030167,0.00004328021,0.0000081372,0.002102527],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006098556,"threshold_uncertainty_score":0.02040172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1744871547135307,"score_gpt":0.422205049717559,"score_spread":0.2477178950040284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}