{"id":"W2887646904","doi":"10.1161/circ.132.suppl_3.16485","title":"Abstract 16485: Hyperinsulinemia Reduces Autophagy in Insulin Resistant Hearts Through Insulin Growth Factor 1 Receptor (IGF-1R) Signaling","year":2015,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brandon University","funders":"","keywords":"Autophagy; Hyperinsulinemia; Internal medicine; Medicine; Endocrinology; Insulin resistance; Insulin; Insulin receptor; Biology; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001885255,0.0004587809,0.0004888508,0.0003036648,0.0001485971,0.0003127219,0.0002541229,0.0004550638,0.003771407],"category_scores_gemma":[0.00009840887,0.0002283987,0.0004196089,0.0001781722,0.0003714437,0.000289294,0.0002374774,0.001289672,0.0005997307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001768773,"about_ca_system_score_gemma":0.0002722543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002635879,"about_ca_topic_score_gemma":0.000417788,"domain_scores_codex":[0.9998614,0.0000182664,0.00002193644,0.00003255855,0.00003331321,0.00003261058],"domain_scores_gemma":[0.9999005,0.00001043323,0.00003580434,0.00000999364,0.000006426733,0.00003696425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002164563,0.0002828614,0.0003383736,0.000155695,0.00002291904,0.00009346899,0.00001866367,0.0000474612,0.9944459,0.00008129622,0.0002429551,0.00210584],"study_design_scores_gemma":[0.001473245,0.01075378,0.05010249,0.00008205872,0.0001862784,0.0009469718,0.0001721136,0.001279163,0.9279861,0.0002568223,0.006729181,0.00003170451],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928571,0.001981737,0.001344937,0.0003733658,0.0001869321,0.00007234225,0.0009962521,0.0001750628,0.002012344],"genre_scores_gemma":[0.9903916,0.001244046,0.002268662,0.0005229811,0.00008437114,0.0001979377,0.001205874,0.00005178609,0.004032684],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003771407,"threshold_uncertainty_score":0.01261657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04665507528369139,"score_gpt":0.2769096552089478,"score_spread":0.2302545799252564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}