{"id":"W2887657552","doi":"10.1016/j.jacc.2018.04.089","title":"Clinical Validity of Genes for Heritable Thoracic Aortic Aneurysm and Dissection","year":2018,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":302,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"National Center for Advancing Translational Sciences; National Human Genome Research Institute; British Heart Foundation","keywords":"Medicine; Thoracic aortic aneurysm; Aortic aneurysm; Aneurysm; Dissection (medical); Gene; Radiology; Cardiology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008418587,0.00007249839,0.0004420649,0.00004549185,0.00005048735,0.000001856333,0.0002052119,0.00005588789,0.000002113207],"category_scores_gemma":[0.0008364683,0.00005207296,0.0002471255,0.0001307095,0.0009318543,0.000003527945,0.0001093065,0.0000842098,1.306868e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008229843,"about_ca_system_score_gemma":0.0001241024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006570585,"about_ca_topic_score_gemma":0.00001461612,"domain_scores_codex":[0.9988266,0.0004328857,0.0003731489,0.0001304851,0.0001028145,0.0001341232],"domain_scores_gemma":[0.9985507,0.0001570986,0.0004963783,0.0002164468,0.0005358533,0.00004357209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001934753,0.00005091428,0.4948541,0.00004380378,0.0003378463,0.000005664156,0.00001231022,0.00002763472,0.4914736,0.00002534752,0.002179844,0.009054138],"study_design_scores_gemma":[0.001596608,0.01714248,0.6669329,0.00003992745,0.0002870879,0.001479236,0.00100313,0.0001604748,0.2853432,0.001092667,0.02467601,0.0002462566],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961172,0.0005427957,0.002550021,0.0002510951,0.0002440275,0.0001553489,0.00004046871,8.272483e-7,0.00009817457],"genre_scores_gemma":[0.9983716,0.0004608174,0.0005900578,0.00002838641,0.0004449866,0.000003447421,8.49798e-7,0.000009630992,0.00009020201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2061304,"threshold_uncertainty_score":0.3433456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04033150899356893,"score_gpt":0.3890059340619302,"score_spread":0.3486744250683613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}