{"id":"W2887828489","doi":"10.1089/hum.2018.111","title":"Evaluating Nonintegrating Lentiviruses as Safe Vectors for Noninvasive Reporter-Based Molecular Imaging of Multipotent Mesenchymal Stem Cells","year":2018,"lang":"en","type":"article","venue":"Human Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University; Robarts Clinical Trials","funders":"","keywords":"Bioluminescence imaging; Mesenchymal stem cell; Reporter gene; Biology; Stem cell; Cell biology; In vivo; Cancer research; Genetic enhancement; Viral vector; Gene delivery; Insertional mutagenesis; Molecular biology; Gene expression; Cell culture; Transfection; Gene; Luciferase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001191278,0.0003717826,0.000364019,0.0001545286,0.0003264123,0.00005569602,0.0004404666,0.0001279088,0.0001195753],"category_scores_gemma":[0.00006711864,0.0003514353,0.0003446053,0.0001522858,0.000316706,0.000009120951,0.00008278761,0.0001181527,0.00001027991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004753413,"about_ca_system_score_gemma":0.000412116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006324489,"about_ca_topic_score_gemma":0.00009950445,"domain_scores_codex":[0.9971859,0.0003018916,0.0006224965,0.0007650069,0.0004977912,0.0006269222],"domain_scores_gemma":[0.9977168,0.00006090073,0.00054257,0.000860279,0.000689939,0.0001295421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001609156,0.000159047,0.0008301897,0.00002608415,0.0001956045,0.00001286712,0.0002619445,0.0004074851,0.9836599,0.00001187483,0.00008576294,0.01274007],"study_design_scores_gemma":[0.002497758,0.008037857,0.00009351061,0.00004885042,0.00002527574,0.00001358498,0.0001861608,0.0009867453,0.9872057,0.00006482057,0.0004788083,0.0003609346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992092,0.001051822,0.005149087,0.00004668624,0.0001758118,0.001189121,0.00003427522,0.00002934231,0.0002318251],"genre_scores_gemma":[0.9948356,0.00005044472,0.003682941,0.0004224883,0.0004065242,0.000189664,0.00008339923,0.0001141259,0.0002148561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01237914,"threshold_uncertainty_score":0.9998938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07285013246421053,"score_gpt":0.3867389118896804,"score_spread":0.3138887794254699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}