{"id":"W2887856562","doi":"10.1016/j.clbc.2018.07.007","title":"Expanded-Access Study of Palbociclib in Combination With Letrozole for Treatment of Postmenopausal Women With Hormone Receptor–Positive, HER2-Negative Advanced Breast Cancer","year":2018,"lang":"en","type":"article","venue":"Clinical Breast Cancer","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Pfizer (Canada); Ottawa Hospital","funders":"MedImmune; AbbVie; Puma Biotechnology; Novartis; Pfizer; Eli Lilly and Company","keywords":"Palbociclib; Medicine; Letrozole; Neutropenia; Metastatic breast cancer; Breast cancer; Adverse effect; Internal medicine; Oncology; Febrile neutropenia; Expanded access; Fulvestrant; Cancer; Estrogen receptor; Chemotherapy; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000247954,0.0004535238,0.001441494,0.0001734947,0.00008495415,0.00001492266,0.0002146867,0.000139273,0.0002534323],"category_scores_gemma":[0.00002647338,0.000316132,0.00008384534,0.0007049736,0.0008368206,0.0003858104,0.00005310157,0.0001628925,0.000001794871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00101645,"about_ca_system_score_gemma":0.0005904843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00194332,"about_ca_topic_score_gemma":0.002440752,"domain_scores_codex":[0.9970068,0.0001547182,0.0009878307,0.0007904835,0.0004946551,0.0005654601],"domain_scores_gemma":[0.9967917,0.0003806862,0.0007975957,0.0004958756,0.001278122,0.0002560248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1775569,0.01191659,0.514506,0.0001369731,0.001519397,0.00001358821,0.005175041,0.0001498263,0.004909039,0.00002405264,0.00002801427,0.2840646],"study_design_scores_gemma":[0.05312357,0.04021123,0.8981829,0.0006791081,0.0002667239,0.0000391779,0.003507238,0.00003558154,0.003402768,0.00007271128,0.0001304994,0.0003484483],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938944,0.0003521009,0.0002048913,0.001147287,0.0001844083,0.003130587,0.0009715686,0.00004640237,0.00006837484],"genre_scores_gemma":[0.9955575,0.0003736052,0.0008299638,0.0002187678,0.0003561986,0.002396051,0.00002928256,0.00009543888,0.0001432334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3836769,"threshold_uncertainty_score":0.9999291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03019194093956165,"score_gpt":0.3880714022082197,"score_spread":0.3578794612686581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}