{"id":"W2887856562","doi":"10.1016/j.clbc.2018.07.007","title":"Expanded-Access Study of Palbociclib in Combination With Letrozole for Treatment of Postmenopausal Women With Hormone Receptor–Positive, HER2-Negative Advanced Breast Cancer","year":2018,"lang":"en","type":"article","venue":"Clinical Breast Cancer","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Pfizer (Canada); Ottawa Hospital","funders":"MedImmune; AbbVie; Puma Biotechnology; Novartis; Pfizer; Eli Lilly and Company","keywords":"Palbociclib; Medicine; Letrozole; Neutropenia; Metastatic breast cancer; Breast cancer; Adverse effect; Internal medicine; Oncology; Febrile neutropenia; Expanded access; Fulvestrant; Cancer; Estrogen receptor; Chemotherapy; Tamoxifen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001115449,0.001163772,0.002804783,0.0006053195,0.0004355687,0.001221764,0.0007652872,0.001232623,0.01012314],"category_scores_gemma":[0.001222761,0.0005392357,0.001386423,0.0005194036,0.0006995195,0.001412325,0.0005146745,0.003146084,0.001908858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009103084,"about_ca_system_score_gemma":0.001220469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002579609,"about_ca_topic_score_gemma":0.006334886,"domain_scores_codex":[0.9993311,0.0002905365,0.00003138812,0.0001145649,0.00007922279,0.0001533125],"domain_scores_gemma":[0.9994079,0.0001074065,0.00006865743,0.00006278881,0.00004249322,0.0003107482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9407349,0.01862315,0.003390405,0.0002407082,0.00162297,0.0001805963,0.00006751785,0.0003868939,0.005240736,0.00009828455,0.001616297,0.02779764],"study_design_scores_gemma":[0.7747529,0.1958709,0.02011507,0.00004670768,0.00204865,0.0001922165,0.00009252065,0.000683754,0.001085228,0.0002230804,0.004844135,0.00004479817],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875361,0.00300525,0.0002916575,0.000616867,0.0002547179,0.00111185,0.002750022,0.0001051671,0.004328311],"genre_scores_gemma":[0.9847568,0.002070824,0.000590597,0.001140253,0.0003283596,0.001047695,0.003581509,0.00004396085,0.006440045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01012314,"threshold_uncertainty_score":0.03386527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03019194093956165,"score_gpt":0.3880714022082197,"score_spread":0.3578794612686581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}