{"id":"W2887883897","doi":"10.1158/1538-7445.am2018-5476","title":"Abstract 5476: Inhibiting lactate transporters MCT-1 and MCT-4 target hypoxic HNSCC cells and sensitize them to metformin","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Metformin; Hypoxia (environmental); Head and neck squamous-cell carcinoma; Radioresistance; Extracellular; Biology; Cancer research; Glycolysis; Glucose transporter; Chemistry; Cell culture; Pharmacology; Cell biology; Metabolism; Oxygen; Internal medicine; Biochemistry; Endocrinology; Medicine; Cancer; Head and neck cancer; Diabetes mellitus; Insulin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001388614,0.0003341989,0.0003951367,0.0002509596,0.0002083298,0.0002952869,0.0002754288,0.0003641083,0.003498523],"category_scores_gemma":[0.0001015545,0.0001345126,0.0003919085,0.0002056663,0.0001862384,0.0001883438,0.0002059416,0.0006255231,0.0008194568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003559761,"about_ca_system_score_gemma":0.0003740765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001863151,"about_ca_topic_score_gemma":0.002162471,"domain_scores_codex":[0.9998361,0.00001219948,0.00001814918,0.00003070653,0.0000662387,0.00003660132],"domain_scores_gemma":[0.9999391,0.000008707473,0.00001321483,0.000006648688,0.00001603059,0.0000163913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002613055,0.00008070278,0.0003108998,0.0001331367,0.00001366856,0.00005854138,0.00001673817,0.0001907831,0.9939288,0.0001451246,0.0006649331,0.004195511],"study_design_scores_gemma":[0.00004575386,0.0004431426,0.002927926,0.00001440234,0.00003141287,0.0001708462,0.0000267596,0.0009410461,0.9871071,0.00004107785,0.008243459,0.000006952437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713696,0.005036655,0.007712765,0.0006817824,0.0003493275,0.0002150439,0.005227425,0.0006275476,0.008779777],"genre_scores_gemma":[0.9662989,0.002964785,0.008634016,0.000309601,0.00003279524,0.0002704609,0.004817015,0.00009458392,0.01657774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003498523,"threshold_uncertainty_score":0.01170373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04117236145479732,"score_gpt":0.333185373582648,"score_spread":0.2920130121278507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}