{"id":"W2887908790","doi":"10.1016/j.xphs.2018.08.005","title":"Protective Efficacy of Candidate Vaccines Prior to Human Clinical Trials","year":2018,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sanofi (Canada)","funders":"Sanofi Pasteur","keywords":"Clinical trial; Vaccine efficacy; Medicine; Immunization; Clinical efficacy; Human use; Immunology; Pharmacology; Vaccination; Biotechnology; Biology; Pathology; Immune system; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004941166,0.0006793477,0.001161986,0.0004154072,0.0004223752,0.001555067,0.0004408121,0.001121466,0.009460549],"category_scores_gemma":[0.004566751,0.0002706234,0.000695769,0.000254352,0.0006185609,0.00107041,0.0004282207,0.002542864,0.002431435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004876335,"about_ca_system_score_gemma":0.001216064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001656586,"about_ca_topic_score_gemma":0.0002513444,"domain_scores_codex":[0.9981375,0.0009817423,0.0001164502,0.0001288099,0.0002658635,0.0003696105],"domain_scores_gemma":[0.9981294,0.0007209437,0.0002609997,0.0003125158,0.0002606694,0.000315382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1342423,0.01824524,0.008616419,0.002617026,0.0006004955,0.000565512,0.000460985,0.003014759,0.312794,0.007844945,0.01718773,0.4938106],"study_design_scores_gemma":[0.01921507,0.4278514,0.02870268,0.001139943,0.001196928,0.001271976,0.0003095661,0.002469654,0.3518052,0.004606044,0.1613471,0.00008451146],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8971157,0.03989103,0.01422476,0.003722626,0.00231012,0.006424246,0.002628168,0.0005084716,0.0331748],"genre_scores_gemma":[0.981241,0.005352483,0.002890251,0.0009763711,0.0004365204,0.001436558,0.001658437,0.00004734935,0.005960951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009460549,"threshold_uncertainty_score":0.03164864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1816586250549008,"score_gpt":0.5165153955090942,"score_spread":0.3348567704541934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}