{"id":"W2887912457","doi":"10.3389/fimmu.2018.01871","title":"Host Defense Peptide LL-37-Mediated Chemoattractant Properties, but Not Anti-Inflammatory Cytokine IL-1RA Production, Is Selectively Controlled by Cdc42 Rho GTPase via G Protein-Coupled Receptors and JNK Mitogen-Activated Protein Kinase","year":2018,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Manitoba","keywords":"CDC42; Cell biology; Chemokine; GTPase; RAC1; MAPK/ERK pathway; Cytokine; Rac GTP-Binding Proteins; Signal transduction; Biology; Receptor; Immune system; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001337439,0.0007495375,0.0003902836,0.0002532983,0.0001523626,0.0003232475,0.0001390829,0.0002153903,0.001986879],"category_scores_gemma":[0.0001339732,0.0001674292,0.000432046,0.0001396671,0.0003792915,0.0001724341,0.0002615719,0.0005805713,0.0006349955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003605333,"about_ca_system_score_gemma":0.0003736848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004404257,"about_ca_topic_score_gemma":0.0006644749,"domain_scores_codex":[0.9997076,0.0000487291,0.00002308844,0.00004304653,0.00006789564,0.0001094539],"domain_scores_gemma":[0.9998645,0.00002041298,0.00003827719,0.00001900729,0.0000115731,0.00004628679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001079276,0.00001736031,0.00007991603,0.00002983064,0.000001849455,0.00005450491,0.000009283466,0.00002538376,0.999124,0.00003489669,0.00001776299,0.0004972321],"study_design_scores_gemma":[0.00001603438,0.0004277203,0.00421515,0.000007010309,0.000008656938,0.0003380353,0.00002471687,0.0002916991,0.9932442,0.00004344002,0.001378511,0.000004804789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940181,0.002454095,0.00151229,0.0001264318,0.00003307093,0.00004197183,0.000391949,0.00005415629,0.00136788],"genre_scores_gemma":[0.9946326,0.001126218,0.00147898,0.0000611946,0.00002149563,0.00007750934,0.0006677898,0.00001378128,0.001920417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001986879,"threshold_uncertainty_score":0.006646812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006520960820027864,"score_gpt":0.1857284488449721,"score_spread":0.1792074880249442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}