{"id":"W2887912457","doi":"10.3389/fimmu.2018.01871","title":"Host Defense Peptide LL-37-Mediated Chemoattractant Properties, but Not Anti-Inflammatory Cytokine IL-1RA Production, Is Selectively Controlled by Cdc42 Rho GTPase via G Protein-Coupled Receptors and JNK Mitogen-Activated Protein Kinase","year":2018,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Manitoba","keywords":"CDC42; Cell biology; Chemokine; GTPase; RAC1; MAPK/ERK pathway; Cytokine; Rac GTP-Binding Proteins; Signal transduction; Biology; Receptor; Immune system; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0006456687,0.0009348901,0.001730073,0.0005035434,0.0007467694,0.00007200797,0.0004864078,0.001088115,0.0002529393],"category_scores_gemma":[0.0007670815,0.0008395482,0.0002193375,0.0005765766,0.002852113,0.0005411099,0.0002432839,0.001275609,0.0001541353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003811493,"about_ca_system_score_gemma":0.0003955145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007837082,"about_ca_topic_score_gemma":0.00006714139,"domain_scores_codex":[0.9950836,0.0007186761,0.001215209,0.001409772,0.0001321744,0.001440615],"domain_scores_gemma":[0.9977903,0.0000766223,0.0008058344,0.0006934698,0.0005429267,0.00009082087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01282518,0.0005046502,0.001335573,0.00008781365,0.001248883,0.00002668274,0.001433195,6.825318e-7,0.9634456,0.00001463529,0.0182351,0.000842028],"study_design_scores_gemma":[0.01042674,0.0009817765,0.001433655,0.0002429591,0.0001141393,0.0001563046,0.001053142,0.00004228328,0.963309,0.00003809141,0.02123559,0.0009663234],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865999,0.004388263,0.0002796605,0.001234039,0.002792485,0.00412335,0.0002173704,0.0003003812,0.00006459425],"genre_scores_gemma":[0.9870123,0.0004689999,0.0005835762,0.0003079322,0.0001866112,0.0006721382,0.0002558956,0.0001400773,0.01037245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01030785,"threshold_uncertainty_score":0.9998615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006520960820027864,"score_gpt":0.1857284488449721,"score_spread":0.1792074880249442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}