{"id":"W2887987288","doi":"10.1056/nejmoa1711460","title":"Phase 3 Study of Ibalizumab for Multidrug-Resistant HIV-1","year":2018,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":223,"is_retracted":false,"has_abstract":true,"ca_institutions":"Theratechnologies (Canada)","funders":"","keywords":"Liter; Viral load; Medicine; Regimen; Population; Internal medicine; Immunology; Human immunodeficiency virus (HIV); Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001469185,0.001261011,0.001437677,0.0003954176,0.0006012328,0.001237394,0.0009429281,0.001204147,0.005692413],"category_scores_gemma":[0.0009468845,0.0005370306,0.001278306,0.0003120188,0.0005164187,0.0006679342,0.0002624156,0.003447132,0.001309622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001160207,"about_ca_system_score_gemma":0.002042317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00213242,"about_ca_topic_score_gemma":0.004117059,"domain_scores_codex":[0.9995969,0.0001925825,0.00001429855,0.00005559966,0.00005040165,0.00009021746],"domain_scores_gemma":[0.9993969,0.0001117717,0.0001140848,0.00005653785,0.00006336615,0.0002573085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6673172,0.09602855,0.009623576,0.00132234,0.00306793,0.0006621521,0.0005408246,0.003484968,0.07154717,0.0005722065,0.01697201,0.1288611],"study_design_scores_gemma":[0.7236599,0.2409531,0.01963148,0.0001005011,0.0006089281,0.0005723645,0.00006726211,0.002128045,0.005738146,0.0003382398,0.006164327,0.00003762843],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806852,0.004044439,0.001435788,0.001268299,0.0002512657,0.005237838,0.002823603,0.0002473402,0.004006322],"genre_scores_gemma":[0.9782835,0.002228806,0.003172071,0.002205717,0.0001865151,0.005344132,0.004389836,0.00008988343,0.004099552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005692413,"threshold_uncertainty_score":0.01904303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01994895119984686,"score_gpt":0.3049404338353641,"score_spread":0.2849914826355173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}