{"id":"W2887992949","doi":"10.1021/acsabm.8b00342","title":"IL-10 Gene Transfection in Primary Endothelial Cells via Linear and Branched Poly(β-amino ester) Nanoparticles Attenuates Inflammation in Stimulated Macrophages","year":2018,"lang":"en","type":"article","venue":"ACS Applied Bio Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Transfection; Gene delivery; Tumor necrosis factor alpha; Lipopolysaccharide; Inflammation; Cytokine; Chemistry; Molecular biology; Cell biology; Biology; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002235944,0.0001903033,0.0002249431,0.0000874246,0.00004150083,0.00004887515,0.0001035608,0.0002035272,0.00004758557],"category_scores_gemma":[0.000007378708,0.000180697,0.00001935996,0.00009197622,0.0001020793,0.00001240259,0.00005924062,0.00004269565,0.00005391729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000176808,"about_ca_system_score_gemma":0.00002229819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009327839,"about_ca_topic_score_gemma":0.0000714828,"domain_scores_codex":[0.9988614,0.00006110941,0.0003809737,0.0003625463,0.00008238245,0.0002516076],"domain_scores_gemma":[0.9996505,0.00001078493,0.00007914432,0.0001803598,0.00004104574,0.00003819625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007514474,0.00004307012,0.0002589838,0.00003582599,0.00001693384,0.000003382862,0.0001577666,0.00001237297,0.9943213,0.000002142945,0.00001740042,0.00437935],"study_design_scores_gemma":[0.001214661,0.0002634659,0.009099007,0.00001840879,0.00001227193,0.000005275314,0.00001640116,0.00001890836,0.9889308,0.00004351437,0.0001769057,0.0002003369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991674,0.00009068831,0.00008498897,0.00003817672,0.0001461069,0.0003467179,0.00007304688,0.00001649863,0.00003632016],"genre_scores_gemma":[0.9988385,0.0001776295,0.0001965023,0.0001316637,0.0003458129,0.00004311596,0.0001907215,0.00002236677,0.00005363454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008840024,"threshold_uncertainty_score":0.7368609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006779167121320023,"score_gpt":0.2186096534869936,"score_spread":0.2118304863656736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}