{"id":"W2887992949","doi":"10.1021/acsabm.8b00342","title":"IL-10 Gene Transfection in Primary Endothelial Cells via Linear and Branched Poly(β-amino ester) Nanoparticles Attenuates Inflammation in Stimulated Macrophages","year":2018,"lang":"en","type":"article","venue":"ACS Applied Bio Materials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Transfection; Gene delivery; Tumor necrosis factor alpha; Lipopolysaccharide; Inflammation; Cytokine; Chemistry; Molecular biology; Cell biology; Biology; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001793044,0.0002906847,0.0001791858,0.0001261197,0.00005595516,0.0001680046,0.00008965779,0.0002087648,0.0007826381],"category_scores_gemma":[0.00009473676,0.0001360688,0.0001744374,0.00008081074,0.0001313333,0.0001490046,0.000115331,0.0003726491,0.0002015603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007985846,"about_ca_system_score_gemma":0.00009080586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000181315,"about_ca_topic_score_gemma":0.0003119498,"domain_scores_codex":[0.9998887,0.00002422478,0.00001179759,0.00002260969,0.00002680994,0.00002588508],"domain_scores_gemma":[0.9999418,0.00001652361,0.00001552738,0.00000569877,0.000008864463,0.00001167728],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004611766,0.00001618367,0.00002716881,0.00001303516,0.000001557234,0.00001111314,0.00000434944,0.00003158227,0.9994265,0.000009730756,0.000006419094,0.0004063685],"study_design_scores_gemma":[0.000005134699,0.0002517259,0.0005254591,0.000002072462,0.000005381744,0.00003407835,0.000005326853,0.0002890332,0.9985495,0.00000748862,0.0003236991,0.000001149526],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938654,0.0006923237,0.004242619,0.00004493398,0.00002050855,0.00002759106,0.0001162382,0.00005367855,0.0009366819],"genre_scores_gemma":[0.990703,0.0008764092,0.00512275,0.00007232241,0.000008365494,0.00006530309,0.0002157494,0.00001659147,0.002919486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007826381,"threshold_uncertainty_score":0.002618194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006779167121320023,"score_gpt":0.2186096534869936,"score_spread":0.2118304863656736,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}