{"id":"W2888002058","doi":"10.3390/ph11030080","title":"pH-Control in Aptamer-Based Diagnostics, Therapeutics, and Analytical Applications","year":2018,"lang":"en","type":"review","venue":"Pharmaceuticals","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Aptamer; Nanotechnology; USable; Nucleic acid; Drug delivery; Chemistry; Computational biology; Computer science; Biology; Materials science; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005573512,0.000766948,0.0008856969,0.002285619,0.0003178647,0.0008507281,0.0006563099,0.001080838,0.003193019],"category_scores_gemma":[0.0005037358,0.0004237496,0.0004818757,0.002123793,0.0005152526,0.001398627,0.0005877214,0.001678127,0.002085869],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005993782,"about_ca_system_score_gemma":0.0007580193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008098662,"about_ca_topic_score_gemma":0.001270472,"domain_scores_codex":[0.9997689,0.00002947997,0.00003010738,0.00004750761,0.00009700788,0.00002695055],"domain_scores_gemma":[0.9997819,0.0001073967,0.00003207242,0.000007710268,0.00005501976,0.00001586686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005995552,0.0001261891,0.0002017427,0.0254121,0.00005413865,0.0003569285,0.000126376,0.0008148722,0.01188753,0.01341559,0.01784514,0.9296993],"study_design_scores_gemma":[0.000006044831,0.00008264057,0.0003404203,0.001538368,0.00003291237,0.001051899,0.00004357154,0.0001264744,0.002502529,0.001679427,0.9925804,0.00001538989],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002996627,0.9962108,0.0004555651,0.0001611887,0.0002258688,0.000008210112,0.00001692285,0.00001002165,0.002611736],"genre_scores_gemma":[0.001658239,0.9960791,0.0005064257,0.0001377942,0.0001289119,0.00001188093,0.00002526428,0.0000025682,0.001449736],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003193019,"threshold_uncertainty_score":0.01068175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06916001976184948,"score_gpt":0.4357307530526353,"score_spread":0.3665707332907858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}