{"id":"W2888013365","doi":"10.1016/j.exphem.2018.06.095","title":"In Vivo Profiling of Leukemic Stem Cell Fitness Identifies Therapeutically Actionable Determinants of Growth","year":2018,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"In vivo; Biology; Bone marrow; Myeloid leukemia; Leukemia; Stem cell; Genetic screen; Cancer research; Computational biology; Gene; Genetics; Immunology; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001814788,0.0003630039,0.0002893269,0.0003268733,0.0001718283,0.0004816476,0.0001555245,0.0002374942,0.001748121],"category_scores_gemma":[0.0001545762,0.0001068162,0.0001446861,0.0002068581,0.000216268,0.000204388,0.0001654143,0.0008007513,0.0003074967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002546442,"about_ca_system_score_gemma":0.000195139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002292285,"about_ca_topic_score_gemma":0.0006070799,"domain_scores_codex":[0.9998312,0.00004158918,0.00000986235,0.00002626179,0.00003654766,0.000054419],"domain_scores_gemma":[0.9998919,0.00003503703,0.0000271275,0.00001152122,0.000007422224,0.0000269458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003042464,0.0001442777,0.0006006984,0.00001031229,0.000003622459,0.00001270254,0.0000206553,0.0001509262,0.9960577,0.0002461681,0.00005853499,0.002390053],"study_design_scores_gemma":[0.00002164832,0.001068057,0.004355162,0.000002988427,0.00002130522,0.00006831447,0.00004459545,0.001775506,0.9917855,0.00009740821,0.0007560854,0.00000339301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954348,0.0004184159,0.002844074,0.00005817404,0.00001348969,0.00003148837,0.0002038014,0.00006594038,0.0009297843],"genre_scores_gemma":[0.9978244,0.0001917152,0.0009117882,0.00002167876,0.000006342801,0.00002666968,0.0001529114,0.00001794942,0.0008465267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001748121,"threshold_uncertainty_score":0.00584805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01644725540273093,"score_gpt":0.2858986865959986,"score_spread":0.2694514311932676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}