{"id":"W2888070818","doi":"10.1016/j.devcel.2018.07.011","title":"Essential Function of Mec1, the Budding Yeast ATM/ATR Checkpoint-Response Kinase, in Protein Homeostasis","year":2018,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"North West Cancer Research","keywords":"Proteostasis; Biology; Cell biology; Synthetic lethality; Saccharomyces cerevisiae; Genetics; Gene; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002186418,0.0004410769,0.0002316082,0.0003046441,0.0003476746,0.0005823564,0.0003206411,0.000359447,0.00144054],"category_scores_gemma":[0.0002125355,0.0001831777,0.0001700184,0.0001469539,0.0002822934,0.0003641904,0.0004221554,0.000433875,0.00090168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007305646,"about_ca_system_score_gemma":0.0004093805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000680711,"about_ca_topic_score_gemma":0.0009426366,"domain_scores_codex":[0.999896,0.00001435826,0.00001192769,0.00002498369,0.00002700758,0.00002564294],"domain_scores_gemma":[0.9998527,0.00002014647,0.00002778397,0.00002331262,0.0000235568,0.00005249633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006386996,0.00002292525,0.0005838001,0.00006651881,0.000008161734,0.0002272921,0.00001108992,0.0001964629,0.9921887,0.0007015362,0.000306414,0.00504841],"study_design_scores_gemma":[0.00003051556,0.00007511507,0.01018427,0.00001019035,0.00002309991,0.0009727471,0.00003156715,0.001384932,0.9817253,0.0004606311,0.005094092,0.000007527466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738705,0.01317725,0.00356326,0.0007338796,0.0001579575,0.00001844949,0.0009913971,0.0003712728,0.007116048],"genre_scores_gemma":[0.9937263,0.001114165,0.0009612488,0.00005171219,0.00001345282,0.00000544661,0.0004551673,0.00002962959,0.003642829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00144054,"threshold_uncertainty_score":0.005300581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00549513457173416,"score_gpt":0.2152523457450853,"score_spread":0.2097572111733511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}