{"id":"W2888114482","doi":"10.18433/jpps28987","title":"Pharmacokinetics of Orally Administered Poly(Ethylene Oxide)-block-Poly(ε-Caprolactone) Micelles of Cyclosporine A in Rats: Comparison with Neoral®","year":2018,"lang":"en","type":"article","venue":"Journal of Pharmacy & Pharmaceutical Sciences","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"King Saud University","keywords":"Pharmacokinetics; Cmax; Ethylene oxide; Micelle; Chemistry; Oral administration; Caprolactone; Pharmacology; Dosage form; Bioavailability; Chromatography; Copolymer; Organic chemistry; Medicine; Aqueous solution; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003692799,0.0006609783,0.001572106,0.0008398899,0.0002554053,0.00004377125,0.001676704,0.0002230172,0.001061801],"category_scores_gemma":[0.0002145756,0.0005177381,0.0003237469,0.002058604,0.003527901,0.0008135049,0.0002785831,0.001697994,0.00003103235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001729513,"about_ca_system_score_gemma":0.0007699776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009740461,"about_ca_topic_score_gemma":0.00005273213,"domain_scores_codex":[0.9925188,0.001167054,0.00307507,0.0006535319,0.001415153,0.001170415],"domain_scores_gemma":[0.9940457,0.001153055,0.002555793,0.0003031294,0.001083403,0.0008589367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01082242,0.00250851,0.1537317,0.0003482659,0.0004716763,0.0002591779,0.001795336,0.0016682,0.771753,0.0002009401,0.001036604,0.05540425],"study_design_scores_gemma":[0.009051326,0.001889714,0.001522764,0.0002604475,0.0005521299,0.000361148,0.0009373608,0.01689227,0.7971528,0.00006205233,0.170772,0.0005459867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803714,0.01330054,0.000419279,0.001831452,0.001674247,0.0005851475,0.00007389386,0.00003995096,0.001704144],"genre_scores_gemma":[0.9916458,0.001477553,0.00505058,0.0009028749,0.0006736927,0.0000132297,0.000003348678,0.0000516825,0.0001813013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1697354,"threshold_uncertainty_score":0.9998513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1571179000331498,"score_gpt":0.4791947240000268,"score_spread":0.322076823966877,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}