{"id":"W2888173740","doi":"10.1038/s41423-018-0160-6","title":"Physiological and druggable skipping of immunoglobulin variable exons in plasma cells","year":2018,"lang":"en","type":"article","venue":"Cellular and Molecular Immunology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital","funders":"Agence Française de Lutte contre le Dopage; Agence Nationale de la Recherche","keywords":"Exon skipping; Exon; RNA splicing; Biology; Intron; Molecular biology; Chromatin; Gene; Cell biology; Genetics; Alternative splicing; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002187254,0.0001992494,0.0002270522,0.0001656921,0.0001574577,0.0002699503,0.0002099578,0.0003369098,0.001467122],"category_scores_gemma":[0.0002963369,0.0001426535,0.0001832799,0.0001376133,0.0003619379,0.0001777285,0.0001542161,0.0003792415,0.0002730143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001860949,"about_ca_system_score_gemma":0.0001746054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003323329,"about_ca_topic_score_gemma":0.0004423466,"domain_scores_codex":[0.9998422,0.00005319305,0.00001721246,0.00002770029,0.00002475911,0.00003501367],"domain_scores_gemma":[0.9998492,0.00007199939,0.00001966312,0.00002937225,0.000008929395,0.00002079789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005346067,0.0000433394,0.0001879643,0.00003400765,0.000008284786,0.0001279498,0.00001564134,0.0002134094,0.9966034,0.0002918294,0.00006350328,0.001876121],"study_design_scores_gemma":[0.00003644497,0.000439207,0.001562656,0.00000299512,0.00001054867,0.0003429634,0.00001561789,0.000556488,0.9956831,0.0001163279,0.001230235,0.000003443373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965503,0.001015353,0.001122292,0.00008718781,0.00003177101,0.00001571914,0.0001731676,0.00004429433,0.0009598584],"genre_scores_gemma":[0.9983091,0.0003251051,0.000363259,0.00003341838,0.000008968019,0.00001244043,0.0001577921,0.00001236285,0.0007775791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001467122,"threshold_uncertainty_score":0.004907966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007372891260862883,"score_gpt":0.2280811289069928,"score_spread":0.22070823764613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}