{"id":"W2888180528","doi":"10.1016/j.cellsig.2018.08.012","title":"TAZ enhances mammary cell proliferation in 3D culture through transcriptional regulation of IRS1","year":2018,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canadian Cancer Society","keywords":"Hippo signaling pathway; Cancer research; IRS1; Biology; Cell biology; Signal transduction; Downregulation and upregulation; Cancer cell; Cell growth; Transcription factor; Matrigel; Effector; Cancer; Insulin receptor; Endocrinology; Gene; Insulin; Genetics; Angiogenesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002648289,0.000156134,0.0001565649,0.00005062827,0.0000862008,0.0000228771,0.0001601209,0.0002257103,0.00005205385],"category_scores_gemma":[0.00001700811,0.0001531922,0.00008533083,0.0001464582,0.00008150877,0.00001862192,0.0000207503,0.0001061034,0.00001141022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001331283,"about_ca_system_score_gemma":0.00008259032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000010908,"about_ca_topic_score_gemma":0.0000167221,"domain_scores_codex":[0.9988328,0.00008967688,0.0003349876,0.0003477065,0.000193661,0.0002011905],"domain_scores_gemma":[0.9994777,0.000007450519,0.0001239174,0.0001899861,0.000163067,0.00003782553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006453446,0.00007641517,0.0002099165,0.000053988,0.000013712,0.000001779451,0.0009532363,0.0006469064,0.9973807,0.0002480474,0.00003424102,0.0003165586],"study_design_scores_gemma":[0.000403845,0.0002759888,0.00009429526,0.00005897416,0.00001294365,0.000002235287,0.00007479767,0.002172566,0.9917924,0.0006177054,0.00431728,0.0001769369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7871881,0.001796292,0.2091,0.00002886311,0.0001327972,0.0001655265,0.000007502531,0.00001349565,0.001567471],"genre_scores_gemma":[0.9897783,0.0001125265,0.008296597,0.00007227534,0.0005266638,0.00001545644,0.0003127647,0.00001845806,0.0008669159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2025903,"threshold_uncertainty_score":0.6246997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01229027892967845,"score_gpt":0.2262568265884954,"score_spread":0.213966547658817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}