{"id":"W2888230285","doi":"10.1038/s41467-018-05861-7","title":"Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":286,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Oda og Hans Svenningsens Fond; H. Lundbeck A/S; Augustinus Fonden; Lundbeckfonden; Aarhus Universitet; Fabrikant Einar Willumsens Mindelegat; Novo Nordisk Fonden; Dagmar Marshalls Fond","keywords":"Sting; Reprogramming; Psychological repression; Regulator; Gene knockdown; Stimulator of interferon genes; Biology; Cell biology; Metabolite; Transcription factor; Inducer; Cytosol; Gene expression; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001320717,0.0003211253,0.0001907278,0.0001590132,0.0001409349,0.000232735,0.0001218327,0.0002023045,0.003336644],"category_scores_gemma":[0.00009798263,0.0000721642,0.000255319,0.0001135672,0.000200122,0.0002879998,0.000154398,0.0002443064,0.0005421547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000219091,"about_ca_system_score_gemma":0.0001469696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002403507,"about_ca_topic_score_gemma":0.0004413217,"domain_scores_codex":[0.9998739,0.00002595958,0.0000110682,0.00003319901,0.00003008907,0.00002579958],"domain_scores_gemma":[0.9999238,0.0000106393,0.00002176624,0.00001343254,0.00001752722,0.00001278868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000099499,0.000007615097,0.0002086023,0.00003291971,0.000003680914,0.00004252669,0.000005865889,0.00002723059,0.9982399,0.0001338861,0.00004359485,0.001154643],"study_design_scores_gemma":[0.00001034732,0.000171229,0.0073371,0.000009098289,0.00001451293,0.0003747145,0.00003224679,0.0005425764,0.9866165,0.0002055377,0.004681826,0.000004386038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785766,0.006360751,0.006589426,0.000455319,0.00008556681,0.00002487625,0.000974037,0.0002127142,0.006720589],"genre_scores_gemma":[0.9931501,0.001230092,0.001185807,0.00008859183,0.00001630954,0.00001485809,0.0006028072,0.00001562843,0.003695833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003336644,"threshold_uncertainty_score":0.01116216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0257016070929467,"score_gpt":0.3150932345733636,"score_spread":0.2893916274804169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}