{"id":"W2888230285","doi":"10.1038/s41467-018-05861-7","title":"Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":286,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Oda og Hans Svenningsens Fond; H. Lundbeck A/S; Augustinus Fonden; Lundbeckfonden; Aarhus Universitet; Fabrikant Einar Willumsens Mindelegat; Novo Nordisk Fonden; Dagmar Marshalls Fond","keywords":"Sting; Reprogramming; Psychological repression; Regulator; Gene knockdown; Stimulator of interferon genes; Biology; Cell biology; Metabolite; Transcription factor; Inducer; Cytosol; Gene expression; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006077882,0.0001796817,0.0002947463,0.0001864841,0.001098507,0.00006338234,0.000565099,0.0004596692,0.00001584723],"category_scores_gemma":[0.001131087,0.0001661296,0.000065923,0.0003270762,0.000997988,0.0001429153,0.0006561973,0.001316534,0.00007638492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002013842,"about_ca_system_score_gemma":0.00005201265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001065893,"about_ca_topic_score_gemma":0.0001065065,"domain_scores_codex":[0.9983917,0.0006179914,0.0003459852,0.0002835088,0.0000362471,0.0003245472],"domain_scores_gemma":[0.9975367,0.000864491,0.0002417689,0.001117573,0.0002178847,0.00002161912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007242124,0.00003396917,0.01725041,0.00001111743,0.0003904644,8.256006e-7,0.004291479,3.687273e-8,0.3427043,0.004924478,0.0004104613,0.6299101],"study_design_scores_gemma":[0.0009822742,0.0002307278,0.1634382,0.0002784451,0.0002097227,0.0001031823,0.001600988,0.000108175,0.4813839,0.0004568106,0.3507002,0.0005073855],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9526457,0.03822106,0.0002510693,0.004084017,0.0002585195,0.0003153782,0.00002368115,0.0002536869,0.003946882],"genre_scores_gemma":[0.9894719,0.0002803715,0.009399948,0.0001848377,0.0001273968,0.000006007902,0.0001009635,0.00002362422,0.0004049786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6294027,"threshold_uncertainty_score":0.8448938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0257016070929467,"score_gpt":0.3150932345733636,"score_spread":0.2893916274804169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}