{"id":"W2888234487","doi":"10.1177/1203475418795823","title":"Refractory Palmoplantar Pustular Psoriasis Treated With High-Dose Ustekinumab After Initial Failure","year":2018,"lang":"en","type":"article","venue":"Journal of Cutaneous Medicine and Surgery","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Guenther Dermatology Research Centre; Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Ustekinumab; Medicine; Refractory (planetary science); Tachyphylaxis; Inflammatory bowel disease; Psoriasis; Dermatology; Plaque psoriasis; Palmoplantar pustulosis; Dosing; Disease; Surgery; Internal medicine; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004990931,0.0005936431,0.001108562,0.0004110072,0.0008475609,0.0005130407,0.0003720447,0.001270829,0.0009138284],"category_scores_gemma":[0.001603232,0.0001824214,0.0005985989,0.0003371332,0.0004413789,0.0004562407,0.0002647094,0.001566406,0.0006160717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004485178,"about_ca_system_score_gemma":0.0002618616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006515837,"about_ca_topic_score_gemma":0.0009674993,"domain_scores_codex":[0.9996488,0.00009235722,0.00003607521,0.0000440898,0.00007875967,0.00009985081],"domain_scores_gemma":[0.9992567,0.0002829986,0.0001030322,0.00006993513,0.00006159606,0.0002257732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.002480224,0.001109484,0.02713611,0.0004966552,0.0002568172,0.8094627,0.001130589,0.001827689,0.03912122,0.001072626,0.004251731,0.1116541],"study_design_scores_gemma":[0.0007680878,0.008393236,0.05616485,0.0002008912,0.0002068367,0.8949802,0.000494903,0.005448304,0.01509561,0.00189357,0.01628575,0.00006775975],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.959226,0.01032932,0.005808125,0.003385739,0.0002807497,0.0003622919,0.0001166805,0.000352813,0.02013826],"genre_scores_gemma":[0.995712,0.0009749879,0.000497821,0.001270389,0.0001804467,0.00002412209,0.00005845388,0.00002380106,0.001258073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001270829,"threshold_uncertainty_score":0.003254294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01514912816761461,"score_gpt":0.2342160495784384,"score_spread":0.2190669214108238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}