{"id":"W2888273825","doi":"10.1111/cts.12578","title":"Evaluation of Pharmacokinetics and Pharmacodynamics of <scp>BI</scp> 425809, a Novel GlyT1 Inhibitor: Translational Studies","year":2018,"lang":"en","type":"article","venue":"Clinical and Translational Science","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Yasuj University of Medical Sciences; Boehringer Ingelheim","keywords":"Pharmacokinetics; Glycine; Pharmacodynamics; Pharmacology; Cerebrospinal fluid; Oral administration; Transporter; Medicine; Bioavailability; Chemistry; Internal medicine; Amino acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009723331,0.0006155372,0.0009019541,0.0002643515,0.000280896,0.000728913,0.0004061449,0.0004639876,0.00153971],"category_scores_gemma":[0.0009417914,0.0003464808,0.0003486202,0.0004398023,0.0004992195,0.0005827867,0.0001571188,0.001382163,0.0006951473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007316923,"about_ca_system_score_gemma":0.001331863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002637295,"about_ca_topic_score_gemma":0.002877542,"domain_scores_codex":[0.9996122,0.0001657586,0.00001981216,0.00005896659,0.00008624988,0.00005714252],"domain_scores_gemma":[0.9997072,0.00006010997,0.00007250024,0.00003080831,0.00004167152,0.00008771534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.06802136,0.00498334,0.002700642,0.0004106698,0.0003912194,0.0003723641,0.0003349989,0.0031203,0.825905,0.0005085649,0.001925688,0.09132572],"study_design_scores_gemma":[0.009757021,0.2805272,0.04516346,0.00007189232,0.001426088,0.002187227,0.0004281359,0.01614107,0.6195616,0.0005638003,0.02403943,0.0001331366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897836,0.002486028,0.003588401,0.0001980478,0.0000436306,0.0004732885,0.000802076,0.000198661,0.002426251],"genre_scores_gemma":[0.9921559,0.001954554,0.002186051,0.0001689182,0.00004869677,0.0003941291,0.001129366,0.00006666344,0.001895548],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002637295,"threshold_uncertainty_score":0.005308807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08557914686407353,"score_gpt":0.4182012557642023,"score_spread":0.3326221089001287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}