{"id":"W2888299140","doi":"10.1371/journal.ppat.1007264","title":"Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis","year":2018,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Ottawa Hospital; Institut National de la Recherche Scientifique; Children's Hospital of Eastern Ontario; University of Ottawa; Armand Frappier Museum; McGill University Health Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Terry Fox Research Institute; Brain Tumour Foundation of Canada; Children's Hospital of Eastern Ontario Foundation; Canadian Cancer Society Research Institute; Cancer Research Society","keywords":"Oncolytic virus; EIF4E; Cancer cell; Biology; Cancer research; Viral replication; PI3K/AKT/mTOR pathway; mTORC1; Cancer; Virology; Virus; Translation (biology); Cell biology; Messenger RNA; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001645622,0.0004326841,0.0004484785,0.0002933208,0.0001659823,0.000388742,0.0002110516,0.0002550242,0.001568749],"category_scores_gemma":[0.000106881,0.0001359868,0.0002765935,0.0001749714,0.0001702572,0.0002717434,0.0002197945,0.0006288538,0.0003228456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002786432,"about_ca_system_score_gemma":0.0003206582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000402853,"about_ca_topic_score_gemma":0.0009529636,"domain_scores_codex":[0.9998437,0.0000236945,0.0000232683,0.00002744359,0.00004350366,0.00003838621],"domain_scores_gemma":[0.9999399,0.00001096025,0.00001628396,0.000008378439,0.000008896231,0.00001548302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004201771,0.0001033592,0.0002224226,0.000143623,0.00001377823,0.00004730008,0.00001522569,0.0002263872,0.9931129,0.0001680483,0.0002047219,0.005322126],"study_design_scores_gemma":[0.00002926525,0.0007304681,0.002196128,0.000007195346,0.00002565231,0.0001826311,0.0000167044,0.00083867,0.9916894,0.00005565265,0.004221562,0.000006550413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857431,0.005729033,0.002737442,0.0001554312,0.0001151147,0.00009174318,0.001425256,0.0002647054,0.003738111],"genre_scores_gemma":[0.9899843,0.002524453,0.003604061,0.0000752756,0.00001824126,0.00006792294,0.001293992,0.00002855808,0.00240318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001568749,"threshold_uncertainty_score":0.005247951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01726671174965486,"score_gpt":0.2845339830668533,"score_spread":0.2672672713171985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}