{"id":"W2888306988","doi":"10.1016/j.exphem.2018.06.195","title":"Mutations in Human Histone H3 are Pre-Leukemic Events and Promote Hematopoietic Stem Cell Expansion and Leukemic Aggressiveness","year":2018,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network; McGill University and Génome Québec Innovation Centre; Jewish General Hospital; Terry Fox Research Institute; McGill University; McGill University Health Centre","funders":"","keywords":"Biology; Histone H3; Epigenetics; Haematopoiesis; Myeloid; Histone; Cancer research; Leukemia; Mutation; Myeloid leukemia; Stem cell; RUNX1; Somatic evolution in cancer; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000127791,0.0001826083,0.0001163927,0.0003276977,0.0001749721,0.000272214,0.0001391284,0.0002199362,0.002650454],"category_scores_gemma":[0.0001777834,0.0001327392,0.0001876113,0.000181853,0.0002640938,0.0001408742,0.0002659154,0.000382947,0.000355062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002722488,"about_ca_system_score_gemma":0.0002089068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008608088,"about_ca_topic_score_gemma":0.001755906,"domain_scores_codex":[0.9998895,0.00002070433,0.00001189871,0.00001464817,0.00002791061,0.00003537851],"domain_scores_gemma":[0.9998862,0.00003273761,0.0000313583,0.00001364298,0.000007185159,0.00002890429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006346196,0.00008301087,0.003903941,0.00001909344,0.00001520388,0.0002051283,0.00001947382,0.0001123077,0.9917437,0.0003339868,0.0001488531,0.002780553],"study_design_scores_gemma":[0.00007225448,0.0004355571,0.04951362,0.000005062964,0.00002822484,0.001286813,0.00008858657,0.001010174,0.9444429,0.000185393,0.00292603,0.000005343865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973114,0.0004606342,0.0007983863,0.00006248291,0.00001648693,0.00001883041,0.0002378888,0.00006491391,0.001029123],"genre_scores_gemma":[0.9986081,0.0001576247,0.0002992735,0.00002502691,0.000004333814,0.000007584581,0.00023615,0.00001311543,0.0006489179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002650454,"threshold_uncertainty_score":0.008866608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861611223063416,"score_gpt":0.3425748609557216,"score_spread":0.3239587487250875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}