{"id":"W2888359735","doi":"10.1016/j.exphem.2018.06.129","title":"Loss-of-Function Mutation in TET2 in Zebrafish Leads to Early MDS Like Phenotype","year":2018,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"","keywords":"GATA1; Zebrafish; RUNX1; Biology; Haematopoiesis; Myeloid leukemia; Phenotype; Myeloid; Bone marrow; Mutant; Cancer research; Progenitor cell; Leukemia; Molecular biology; Mutation; Genetics; Stem cell; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001288227,0.0007491804,0.0003162044,0.0008103387,0.0003621367,0.0002891253,0.000410212,0.001032086,0.006835585],"category_scores_gemma":[0.0002051146,0.0003314258,0.0005886997,0.0001868369,0.0006764708,0.0002710251,0.0005209076,0.001326166,0.00117751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006420932,"about_ca_system_score_gemma":0.0005061624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003295182,"about_ca_topic_score_gemma":0.006681452,"domain_scores_codex":[0.9998208,0.0000140417,0.00001982232,0.00004364062,0.00007040254,0.00003133469],"domain_scores_gemma":[0.9997544,0.00005114945,0.00009259733,0.00001679367,0.00001586101,0.00006927928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006610884,0.00001382531,0.0001567742,0.00002538604,0.000006499276,0.0007853686,0.00002041702,0.0001858552,0.9974963,0.0003308984,0.0001507759,0.0007617506],"study_design_scores_gemma":[0.00009362767,0.0002566772,0.008431499,0.00002861892,0.00006672788,0.002732118,0.0001062174,0.002103581,0.9807252,0.0003684584,0.005055637,0.00003154353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761685,0.0009765328,0.01194096,0.0006955497,0.0002344441,0.00009975825,0.003070083,0.000829593,0.005984619],"genre_scores_gemma":[0.9674631,0.0006266503,0.004278053,0.0001552331,0.00002014625,0.00008816987,0.0008942924,0.0002117232,0.02626248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006835585,"threshold_uncertainty_score":0.02286732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02146988895762444,"score_gpt":0.3384464523761968,"score_spread":0.3169765634185724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}