{"id":"W2888387114","doi":"10.1016/j.exphem.2018.06.038","title":"Translating human development to new therapies with pluripotent stem cells","year":2018,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"","keywords":"Mesoderm; Induced pluripotent stem cell; Biology; Wnt signaling pathway; Nodal signaling; Stem cell; Cell biology; Haematopoiesis; NODAL; Signal transduction; Genetics; Embryonic stem cell; Bioinformatics; Cancer research; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001003529,0.0002330502,0.000224109,0.00007172576,0.000220355,0.00002667294,0.0002921051,0.0001179505,0.0001658601],"category_scores_gemma":[0.000001227742,0.0001982384,0.00004740735,0.00009891649,0.0001493859,0.000004877896,0.0001608806,0.00007643477,0.0002603892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004218065,"about_ca_system_score_gemma":0.0001294004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003122078,"about_ca_topic_score_gemma":0.00008750514,"domain_scores_codex":[0.9984345,0.000062548,0.0002604288,0.0005246822,0.0002276639,0.0004901733],"domain_scores_gemma":[0.9993272,0.000006014572,0.00005388427,0.0003267539,0.00005179154,0.0002343349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002031742,0.0001187395,0.0006269232,0.00001298299,0.00008172602,0.00001988227,0.002361839,0.000003782729,0.9927879,0.0003685463,0.001382775,0.002031755],"study_design_scores_gemma":[0.0009274505,0.001333315,0.00007747916,0.00002519276,0.000003085724,0.00011638,0.0006593778,0.000003687677,0.9683968,0.000004618286,0.02819847,0.0002541621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917117,0.001842554,0.002596701,0.0001853086,0.0001011263,0.00044845,0.000001790572,0.00003391494,0.003078415],"genre_scores_gemma":[0.98842,0.00000277116,0.007437381,0.0002595545,0.0001606375,0.00005965122,0.00001874708,0.00004281114,0.003598414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0268157,"threshold_uncertainty_score":0.8083926,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02455829262355096,"score_gpt":0.3002321535348562,"score_spread":0.2756738609113052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}