{"id":"W2888403349","doi":"10.1128/mbio.01581-18","title":"High-Throughput Screening Identifies Genes Required for <i>Candida albicans</i> Induction of Macrophage Pyroptosis","year":2018,"lang":"en","type":"article","venue":"mBio","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Government of Canada; National Institutes of Health; University of Aberdeen; Canadian Institutes of Health Research; National Institute for Health and Care Research; Genome Canada","keywords":"Pyroptosis; Candida albicans; Macrophage; Biology; Corpus albicans; Innate immune system; Immune system; Microbiology; Inflammasome; Cell biology; Immunology; Inflammation; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001273146,0.000121884,0.000144443,0.0000402796,0.0001347621,0.00002014422,0.000147617,0.00013263,0.0000435801],"category_scores_gemma":[0.00004211602,0.0001213054,0.0001052575,0.00008802462,0.0001983808,0.000009904884,0.00007386379,0.00003403776,0.000007380235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006017135,"about_ca_system_score_gemma":0.00002825801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001840683,"about_ca_topic_score_gemma":0.00007051935,"domain_scores_codex":[0.9991924,0.00002432624,0.0002298115,0.0002557232,0.00008385779,0.0002139496],"domain_scores_gemma":[0.9994001,0.000005791748,0.0001162075,0.0002879393,0.000163961,0.00002602995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001648123,0.0000234077,0.0004109219,0.00002479604,0.00007936692,2.266847e-7,0.0000894461,0.000005922739,0.9839177,0.00006320655,0.003103449,0.01211675],"study_design_scores_gemma":[0.0006547557,0.0003657478,0.0009545459,0.0000139257,0.00002900266,0.000001785054,0.000226696,0.000009992367,0.9546931,0.000121322,0.04278845,0.0001407073],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893029,0.0008580782,0.008680498,0.0001205492,0.0004572786,0.0001968819,0.00003836823,0.00001283601,0.0003325657],"genre_scores_gemma":[0.9954538,0.0001743754,0.002182732,0.0001340201,0.0004180829,0.00003242835,0.0002084255,0.00002416449,0.001372017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.039685,"threshold_uncertainty_score":0.4946692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182107929404513,"score_gpt":0.2513003301792546,"score_spread":0.2394792508852095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}