{"id":"W2888403349","doi":"10.1128/mbio.01581-18","title":"High-Throughput Screening Identifies Genes Required for <i>Candida albicans</i> Induction of Macrophage Pyroptosis","year":2018,"lang":"en","type":"article","venue":"mBio","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Government of Canada; National Institutes of Health; University of Aberdeen; Canadian Institutes of Health Research; National Institute for Health and Care Research; Genome Canada","keywords":"Pyroptosis; Candida albicans; Macrophage; Biology; Corpus albicans; Innate immune system; Immune system; Microbiology; Inflammasome; Cell biology; Immunology; Inflammation; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002963965,0.0004925186,0.0006316822,0.0007465517,0.0002682515,0.0005719992,0.0003486643,0.0003577433,0.001233256],"category_scores_gemma":[0.000385127,0.0001799986,0.0004968084,0.0006755663,0.0002066523,0.0001185965,0.0002881718,0.0004637672,0.0006439307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003359405,"about_ca_system_score_gemma":0.0003808133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008157006,"about_ca_topic_score_gemma":0.001306328,"domain_scores_codex":[0.9995996,0.00004164745,0.00003963857,0.00008097033,0.0001634955,0.00007454892],"domain_scores_gemma":[0.9997383,0.00009660525,0.00006367498,0.00003185217,0.00003422941,0.00003545358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009690815,0.00006191932,0.0006378054,0.00003367346,0.000007974918,0.00005135789,0.000005243028,0.00014032,0.9973637,0.00003241457,0.0001313172,0.001437352],"study_design_scores_gemma":[0.00003287902,0.0005824143,0.02197641,0.00001296994,0.0000594763,0.0005504993,0.00004748254,0.003152062,0.9702285,0.00007573409,0.003261479,0.00002014764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9739937,0.001641218,0.00925615,0.0002593588,0.00004744978,0.0002849021,0.01186954,0.0007141246,0.001933553],"genre_scores_gemma":[0.9585077,0.001089573,0.01762117,0.0003015061,0.00003182321,0.0003175877,0.01899297,0.0001614369,0.002976164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001233256,"threshold_uncertainty_score":0.004125655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182107929404513,"score_gpt":0.2513003301792546,"score_spread":0.2394792508852095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}