{"id":"W2888406730","doi":"10.1002/path.5158","title":"Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury","year":2018,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Manchester Biomedical Research Centre; Medical Research Council Canada; Centers for Disease Control and Prevention; British Heart Foundation; University College London; Great Ormond Street Hospital for Children; King's College London; Kids Kidney Research; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Kidney Research UK; National Institute for Health and Care Research; Wellcome Trust","keywords":"Nephritis; Kidney; Nephrotoxicity; Glomerulus; Context (archaeology); MMP9; Biology; Cell biology; Pathology; Medicine; Gene; Endocrinology; Genetics; Downregulation and upregulation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001845279,0.0004807202,0.000300006,0.0006440117,0.0002674915,0.0005944184,0.0001869518,0.0004428472,0.001144751],"category_scores_gemma":[0.0002058554,0.0001575569,0.0002423816,0.0004064103,0.0004492178,0.0002480567,0.000434271,0.000499716,0.0002760863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00041015,"about_ca_system_score_gemma":0.0002944413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001013926,"about_ca_topic_score_gemma":0.001027691,"domain_scores_codex":[0.9997559,0.00003216789,0.00001229844,0.00007096107,0.00007269196,0.00005592841],"domain_scores_gemma":[0.9998451,0.00001178144,0.00007436697,0.000008933091,0.00001986366,0.00003985241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003455913,0.00002245907,0.007071231,0.0001972389,0.00004807861,0.0009440274,0.00005268059,0.000177855,0.9783021,0.0009587181,0.0004936089,0.01138646],"study_design_scores_gemma":[0.00006130138,0.0005235592,0.1573276,0.00009693734,0.0001956752,0.01194066,0.0003491643,0.00238708,0.782115,0.003023843,0.04192008,0.00005913145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9545444,0.03050958,0.007715347,0.0007280863,0.0001166996,0.00004728681,0.001235331,0.0003461815,0.004756995],"genre_scores_gemma":[0.989947,0.00453194,0.00145022,0.0001432632,0.00002750908,0.00001883381,0.0008479238,0.00002607818,0.003007288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001144751,"threshold_uncertainty_score":0.003829539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00848573339045418,"score_gpt":0.2464693764015493,"score_spread":0.2379836430110951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}