{"id":"W2888416545","doi":"10.1038/s41593-018-0206-1","title":"GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability","year":2018,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":551,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto; McMaster University; Baycrest Hospital; St. Joseph’s Healthcare Hamilton","funders":"National Institute on Drug Abuse; National Institute on Alcohol Abuse and Alcoholism; European Regional Development Fund; National Institute of Mental Health; Medical Research Council; European Commission; National Institute for Health and Care Research; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Vrije Universiteit Amsterdam; National Institutes of Health; Stichting Volksbond Rotterdam","keywords":"Mendelian randomization; Genome-wide association study; Cannabis; Schizophrenia (object-oriented programming); Psychiatry; Single-nucleotide polymorphism; Psychology; Genetic association; Genetics; Medicine; Biology; Gene; Genotype; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006003054,0.0007957664,0.0005413102,0.001392732,0.0008204487,0.001029737,0.0005532823,0.0008981251,0.003752158],"category_scores_gemma":[0.003270686,0.0004847657,0.001167858,0.001321344,0.0005917236,0.0003306731,0.0008708656,0.0008118052,0.0002175652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003496529,"about_ca_system_score_gemma":0.0005496654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01131616,"about_ca_topic_score_gemma":0.01657393,"domain_scores_codex":[0.9989609,0.0002327735,0.0001054185,0.0003256078,0.0002333601,0.0001420107],"domain_scores_gemma":[0.9977226,0.0007501707,0.0007320159,0.0002868127,0.0001675714,0.0003407799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002138839,0.000117429,0.9344215,0.00009699298,0.00179183,0.001776547,0.0004598255,0.0003597264,0.04701244,0.0008497028,0.0005310574,0.01044415],"study_design_scores_gemma":[0.00005595972,0.0001314866,0.9933873,0.00002935528,0.0005383722,0.00195611,0.0001768123,0.0008314555,0.001430691,0.0008674167,0.0005694875,0.00002548875],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962773,0.0007424185,0.001203779,0.0003312014,0.00003685132,0.000009163524,0.0005919921,0.00004734652,0.0007599495],"genre_scores_gemma":[0.9984789,0.0002175446,0.0006924163,0.00005080498,0.0000229079,0.000004912159,0.0002159546,0.00001863655,0.0002979293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01131616,"threshold_uncertainty_score":0.02250057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006077923488203067,"score_gpt":0.2784133826675831,"score_spread":0.2723354591793801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}