{"id":"W2888496958","doi":"10.1002/ajh.25259","title":"Single‐agent ibrutinib versus chemoimmunotherapy regimens for treatment‐naïve patients with chronic lymphocytic leukemia: A cross‐trial comparison of phase 3 studies","year":2018,"lang":"en","type":"article","venue":"American Journal of Hematology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Cilag; Pharmacyclics","keywords":"Ibrutinib; Chlorambucil; Obinutuzumab; Chemoimmunotherapy; Medicine; Ofatumumab; Fludarabine; Chronic lymphocytic leukemia; Internal medicine; Rituximab; Bendamustine; Oncology; Cyclophosphamide; Alemtuzumab; Neutropenia; Venetoclax; Leukemia; Chemotherapy; Lymphoma; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000274498,0.0003295925,0.002010337,0.000266029,0.0001291087,0.00001588993,0.0002428926,0.0001007445,0.00004967515],"category_scores_gemma":[0.0003935696,0.0002251804,0.000304715,0.0003645701,0.002631208,0.00009270696,0.0000472318,0.0001406675,0.000008913943],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.04338792,"about_ca_system_score_gemma":0.01584805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001589857,"about_ca_topic_score_gemma":0.00004114523,"domain_scores_codex":[0.997221,0.0001162273,0.001153886,0.0003276599,0.00055914,0.0006220718],"domain_scores_gemma":[0.9954754,0.0009413218,0.001574298,0.0004874771,0.001317689,0.0002038415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9325014,0.003801913,0.003410942,0.0004024068,0.008463874,0.000241928,0.005236479,0.00006386517,0.003168598,0.0002087212,0.002153562,0.04034634],"study_design_scores_gemma":[0.7007091,0.2267767,0.00007825063,0.0003717252,0.0007116428,0.0007177948,0.001478884,0.0008683064,0.06483337,0.00002037999,0.003196039,0.000237763],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951363,0.002676759,0.000361594,0.0001081287,0.0005794077,0.001008925,0.00001459687,0.00001869848,0.00009565074],"genre_scores_gemma":[0.9972745,0.0001801898,0.00185182,0.00006218396,0.0004449382,0.00004247427,0.00001298959,0.00005627259,0.0000745884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2317922,"threshold_uncertainty_score":0.9897312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0710266598013649,"score_gpt":0.4305795569839129,"score_spread":0.359552897182548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}