{"id":"W2888539885","doi":"10.1371/journal.pntd.0006701","title":"Therapeutic control of leishmaniasis by inhibitors of the mammalian target of rapamycin","year":2018,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Pasteur Institute of Iran; Shiraz University; National Foundation for Science and Technology Development; Iran National Science Foundation; School of Veterinary Science, Shiraz University; National Science Foundation","keywords":"Sirolimus; Leishmania; Leishmaniasis; Splenocyte; Cytokine; Lymph node; PI3K/AKT/mTOR pathway; Parasite load; Meglumine antimoniate; Cutaneous leishmaniasis; Pharmacology; Immunology; Lymph; Leishmania donovani; Leishmania major; Biology; Medicine; Immune system; Parasite hosting; Visceral leishmaniasis; Internal medicine; Signal transduction; Pathology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001374481,0.0003897027,0.0004231772,0.0003205964,0.0001077639,0.0002338188,0.000188311,0.0002484996,0.0009177501],"category_scores_gemma":[0.0000649229,0.00007576901,0.0002470489,0.000188263,0.000180795,0.0001115884,0.0001465289,0.0007506909,0.0002791548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001383315,"about_ca_system_score_gemma":0.0001818864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000210557,"about_ca_topic_score_gemma":0.0005161802,"domain_scores_codex":[0.9999235,0.00001846352,0.00000755967,0.00001179859,0.00001688312,0.00002179307],"domain_scores_gemma":[0.9999647,0.000007004494,0.00001348883,0.000002849859,0.000004372358,0.000007552156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005310553,0.000260626,0.0002418407,0.0003938925,0.00002704643,0.0001343297,0.00001878009,0.0002917423,0.9745975,0.0001932533,0.000446638,0.02286323],"study_design_scores_gemma":[0.0003636227,0.009204679,0.007308828,0.00005226506,0.0001549682,0.001370937,0.00005430136,0.001629576,0.9571668,0.0001509105,0.0225227,0.00002047603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9411445,0.04824224,0.00405623,0.0006560701,0.0002261137,0.0001688466,0.0005951784,0.0003764918,0.004534358],"genre_scores_gemma":[0.9721776,0.02178693,0.003281018,0.0001473105,0.00008018524,0.0001258048,0.000585274,0.00001950876,0.001796424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009177501,"threshold_uncertainty_score":0.003070235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414547522893438,"score_gpt":0.257455890675967,"score_spread":0.2433104154470326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}