{"id":"W2888539885","doi":"10.1371/journal.pntd.0006701","title":"Therapeutic control of leishmaniasis by inhibitors of the mammalian target of rapamycin","year":2018,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research; Pasteur Institute of Iran; Shiraz University; National Foundation for Science and Technology Development; Iran National Science Foundation; School of Veterinary Science, Shiraz University; National Science Foundation","keywords":"Sirolimus; Leishmania; Leishmaniasis; Splenocyte; Cytokine; Lymph node; PI3K/AKT/mTOR pathway; Parasite load; Meglumine antimoniate; Cutaneous leishmaniasis; Pharmacology; Immunology; Lymph; Leishmania donovani; Leishmania major; Biology; Medicine; Immune system; Parasite hosting; Visceral leishmaniasis; Internal medicine; Signal transduction; Pathology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00001078363,0.0002139003,0.0007608611,0.0001234127,0.00008419617,0.000007003272,0.0003032053,0.00009084321,0.0004117764],"category_scores_gemma":[0.001264329,0.0001342183,0.0003327114,0.000615872,0.00128089,0.00006080581,0.00009954168,0.0001817183,0.000007524324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004905761,"about_ca_system_score_gemma":0.0001794075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005057226,"about_ca_topic_score_gemma":0.00001307415,"domain_scores_codex":[0.9975607,0.0002860128,0.0006128975,0.0002873372,0.0008828567,0.0003701561],"domain_scores_gemma":[0.9979101,0.0003453414,0.0002690476,0.0005636581,0.00071799,0.000193876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001261168,0.001608915,0.410076,0.0004011045,0.0007676842,0.000003324182,0.0001351579,5.154113e-7,0.5804867,0.000181123,0.004316438,0.0007619271],"study_design_scores_gemma":[0.002092571,0.001090298,0.755533,0.0002134249,0.0004410724,0.000001378916,0.0000778777,0.00007649495,0.2398255,0.0001899804,0.0003710891,0.0000872696],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993581,0.0026635,0.0001226109,0.001918918,0.00007487741,0.0008454775,0.0003163733,0.0000415137,0.0004357347],"genre_scores_gemma":[0.9992007,0.0000919649,0.00008816076,0.0002397482,0.000155875,0.00004361489,0.00001090032,0.00003231832,0.0001367301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3454571,"threshold_uncertainty_score":0.5473262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414547522893438,"score_gpt":0.257455890675967,"score_spread":0.2433104154470326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}