{"id":"W2888553016","doi":"10.1038/s41420-018-0090-1","title":"DHA and 19,20-EDP induce lysosomal-proteolytic-dependent cytotoxicity through de novo ceramide production in H9c2 cells with a glycolytic profile","year":2018,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta; Canadian Institutes of Health Research; University of Alberta","keywords":"Glycolysis; Cytotoxicity; Ceramide; Metabolite; Programmed cell death; Biochemistry; Oxidative phosphorylation; Biology; Cell biology; Cell culture; Sphingomyelin; Metabolism; Secretion; Apoptosis; In vitro; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002737031,0.0002813909,0.0002569034,0.00006324776,0.0001444885,0.0001129179,0.0001850595,0.0001943004,0.00001601686],"category_scores_gemma":[0.00006895902,0.0002435467,0.00005369113,0.0001625005,0.0001726368,0.00005533945,0.0001465628,0.0001918047,0.00001163695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005753037,"about_ca_system_score_gemma":0.0002706065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001945626,"about_ca_topic_score_gemma":0.0001386755,"domain_scores_codex":[0.9982179,0.00008701839,0.0002693727,0.0007319672,0.0002034411,0.0004902615],"domain_scores_gemma":[0.9992182,0.00001398618,0.000124123,0.0004618693,0.00006764998,0.0001141956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000419081,0.0001685216,0.01004183,0.000102951,0.00002430617,0.00002197673,0.00042041,0.0001883238,0.9883499,0.00006946558,0.000114614,0.00007865512],"study_design_scores_gemma":[0.001166266,0.0003237445,0.004877211,0.00006261412,0.0000435319,0.00006955166,0.0002302687,0.00008775626,0.9920247,0.0001477183,0.0006235697,0.0003431191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946003,0.0005913771,0.001880556,0.00006638284,0.0002419635,0.0007007878,0.0000227756,0.0000219519,0.001873937],"genre_scores_gemma":[0.9945713,0.0001785024,0.001986738,0.0003114826,0.0008373288,0.00009476762,0.00003814844,0.00004566094,0.001936065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005164621,"threshold_uncertainty_score":0.9931545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01168366739618526,"score_gpt":0.2357246152324255,"score_spread":0.2240409478362402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}