{"id":"W2888553016","doi":"10.1038/s41420-018-0090-1","title":"DHA and 19,20-EDP induce lysosomal-proteolytic-dependent cytotoxicity through de novo ceramide production in H9c2 cells with a glycolytic profile","year":2018,"lang":"en","type":"article","venue":"Cell Death Discovery","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta; Canadian Institutes of Health Research; University of Alberta","keywords":"Glycolysis; Cytotoxicity; Ceramide; Metabolite; Programmed cell death; Biochemistry; Oxidative phosphorylation; Biology; Cell biology; Cell culture; Sphingomyelin; Metabolism; Secretion; Apoptosis; In vitro; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001957583,0.0004391,0.0004278932,0.0001833687,0.0002233998,0.000268895,0.0001878128,0.0003089333,0.0008528133],"category_scores_gemma":[0.00008528151,0.0001441655,0.0004297432,0.0002239606,0.0001716682,0.0002263353,0.0002304392,0.0007339868,0.000347476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002530275,"about_ca_system_score_gemma":0.0002087638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001350591,"about_ca_topic_score_gemma":0.001692809,"domain_scores_codex":[0.9997396,0.00003651526,0.00005702578,0.00004644771,0.00006513996,0.00005532069],"domain_scores_gemma":[0.9999132,0.00001503892,0.00001416926,0.00001738248,0.00001708589,0.00002313785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000328306,0.00006499304,0.0002455161,0.00002829634,0.000009310466,0.0001244437,0.00001810221,0.00005660458,0.9985727,0.00003854741,0.00003127943,0.0004819091],"study_design_scores_gemma":[0.0000292894,0.0006229121,0.004384197,0.00000448563,0.00001858471,0.0001624746,0.00003844848,0.0008754324,0.9929373,0.00003354944,0.0008876031,0.000005897222],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941325,0.001306088,0.001649196,0.0001374204,0.00007386848,0.00005054813,0.001076646,0.00003562204,0.001538168],"genre_scores_gemma":[0.9918317,0.0009519816,0.002508546,0.0001442329,0.00002354852,0.00007941882,0.001490674,0.00001353659,0.002956405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001350591,"threshold_uncertainty_score":0.002852976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01168366739618526,"score_gpt":0.2357246152324255,"score_spread":0.2240409478362402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}