{"id":"W2888569846","doi":"10.1371/journal.pone.0199936","title":"Effects of metal ions on caspase-1 activation and interleukin-1β release in murine bone marrow-derived macrophages","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research and Innovation; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs","keywords":"Inflammasome; Chemistry; Caspase 1; Molecular biology; Oxidative stress; Biochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005302955,0.00009986979,0.0001467652,0.00006701732,0.00003121582,0.000005628306,0.00005466309,0.00007159478,0.00001781071],"category_scores_gemma":[0.0001535054,0.00009698381,0.00003008865,0.00006433753,0.00009107113,0.000005156307,0.00005706404,0.00006382379,0.000006895358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000789017,"about_ca_system_score_gemma":0.00001553854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003683497,"about_ca_topic_score_gemma":0.00003326446,"domain_scores_codex":[0.9994296,0.0000439042,0.0001394808,0.0001789853,0.0000787209,0.0001293543],"domain_scores_gemma":[0.9996817,0.00001751587,0.00006045206,0.000160248,0.00005275505,0.00002729898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003080981,0.0005103384,0.0004702874,0.00009730102,0.00009238187,0.000004557116,0.0001093993,7.86717e-7,0.9977518,0.00001737074,0.00003687763,0.0006008128],"study_design_scores_gemma":[0.001006011,0.0008323826,0.01154121,0.0001094892,0.00003493715,0.000001037511,0.00004623692,0.00002048349,0.9862298,0.00002833379,0.00005044995,0.00009966354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990305,0.0003151457,0.00001933767,0.0001159155,0.00001973347,0.0002019551,0.00000371163,0.000005755195,0.0002879286],"genre_scores_gemma":[0.9991733,0.0001820925,0.0001555208,0.0001208164,0.00005776598,0.0000228677,0.00004069771,0.00001397671,0.0002328922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01152202,"threshold_uncertainty_score":0.3954885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008629539311912696,"score_gpt":0.207995281877915,"score_spread":0.1993657425660023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}