{"id":"W2888576105","doi":"10.1021/acs.est.8b02831","title":"Halobenzoquinone-Induced Developmental Toxicity, Oxidative Stress, and Apoptosis in Zebrafish Embryos","year":2018,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Water Treatment and Disinfection","field":"Environmental Science","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"Jianghan University; National Institutes of Health; Alberta Health; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Oxidative stress; Developmental toxicity; Toxicity; Zebrafish; Reactive oxygen species; Glutathione; DNA damage; Superoxide dismutase; Apoptosis; Antioxidant; DNA fragmentation; Chemistry; Dichloroacetic acid; Haloacetic acids; Biology; Andrology; Biochemistry; Toxicology; Programmed cell death; Genetics; Gene; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001026562,0.000276161,0.0001683085,0.0002207842,0.0001429385,0.0001157566,0.0001188673,0.0002116982,0.0005247697],"category_scores_gemma":[0.00009239576,0.0001217032,0.0002407257,0.00008739492,0.000160135,0.0001372012,0.0001498145,0.0002749869,0.00008378389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004435551,"about_ca_system_score_gemma":0.0002594965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002928032,"about_ca_topic_score_gemma":0.004827014,"domain_scores_codex":[0.9999304,0.000009588463,0.000007036551,0.00001496314,0.00002500066,0.00001298657],"domain_scores_gemma":[0.9999416,0.000007598926,0.00002279625,0.000003713026,0.0000167269,0.000007582392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004999224,0.000005757987,0.0005874206,0.00003767111,0.000004757179,0.00006072082,0.00002099084,0.00003628279,0.9982457,0.00002237613,0.00001866932,0.0009095667],"study_design_scores_gemma":[0.00001001247,0.0005507754,0.03066366,0.00001336076,0.00002109905,0.00018329,0.00005692102,0.0003578317,0.9667037,0.00005262376,0.001379633,0.000007113888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929764,0.003067965,0.002095287,0.00009400789,0.00001559778,0.00004207462,0.0003947081,0.00004402739,0.001269868],"genre_scores_gemma":[0.993378,0.00243009,0.001664338,0.00007925292,0.000005438417,0.00005241212,0.0003387877,0.000006996498,0.0020448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002928032,"threshold_uncertainty_score":0.005821943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007690489710457,"score_gpt":0.2142315980203197,"score_spread":0.2065411083098627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}