{"id":"W2888576105","doi":"10.1021/acs.est.8b02831","title":"Halobenzoquinone-Induced Developmental Toxicity, Oxidative Stress, and Apoptosis in Zebrafish Embryos","year":2018,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Water Treatment and Disinfection","field":"Environmental Science","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"Jianghan University; National Institutes of Health; Alberta Health; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Oxidative stress; Developmental toxicity; Toxicity; Zebrafish; Reactive oxygen species; Glutathione; DNA damage; Superoxide dismutase; Apoptosis; Antioxidant; DNA fragmentation; Chemistry; Dichloroacetic acid; Haloacetic acids; Biology; Andrology; Biochemistry; Toxicology; Programmed cell death; Genetics; Gene; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002131157,0.0002375195,0.0001764027,0.000350835,0.0004634544,0.00005291128,0.0004120847,0.0001522815,0.001140233],"category_scores_gemma":[0.00002519773,0.0002196259,0.00002360009,0.001091063,0.003335301,0.000760557,0.0009384275,0.0001581005,0.0007506012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009316285,"about_ca_system_score_gemma":0.00001759182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002628186,"about_ca_topic_score_gemma":0.0005027155,"domain_scores_codex":[0.9979607,0.00002566166,0.0002325017,0.0007916629,0.0003859615,0.0006035466],"domain_scores_gemma":[0.9995432,0.00001293189,0.00007825601,0.0002324342,0.000002315312,0.0001308238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008233636,0.0001896654,0.409832,8.012494e-7,0.000003118942,0.000004045289,0.0003402486,0.000002634459,0.5832054,0.00006344054,0.00002738807,0.006323077],"study_design_scores_gemma":[0.0003790495,0.000274094,0.2943131,0.00001016286,0.000004951058,0.00002062689,0.0007386304,0.0000466795,0.7031858,0.0005661689,0.0002509636,0.0002098136],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921949,0.00001140035,0.00003424831,0.0003051651,0.0001059678,0.0003159677,0.000007148354,0.00009141269,0.006933798],"genre_scores_gemma":[0.9985656,0.00001437179,0.001098828,0.0001046851,0.00002005489,0.00004166493,0.000005436257,0.00001267055,0.0001366722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1199804,"threshold_uncertainty_score":0.9997728,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007690489710457,"score_gpt":0.2142315980203197,"score_spread":0.2065411083098627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}