{"id":"W2888589055","doi":"10.1038/s41598-018-30788-w","title":"Efficient production of a mature and functional gamma secretase protease","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre; University of Toronto","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Curtin University of Technology; Government of Canada; Alzheimer's Society; Medical Research Council; Centre National de la Recherche Scientifique; National Health and Medical Research Council; Society of Interventional Radiology Foundation","keywords":"Amyloid precursor protein secretase; Proteolysis; Recombinant DNA; Gamma secretase; Amyloid precursor protein; Protease; Enzyme; Biochemistry; Alpha secretase; Target protein; Chemistry; Biology; Cell biology; Gene; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003804443,0.0005575686,0.0003824607,0.0003442719,0.0001997838,0.0007234942,0.0002978701,0.0003628304,0.0006587844],"category_scores_gemma":[0.00019798,0.0002351309,0.0003789356,0.0003385236,0.0002192239,0.0003433177,0.0003953362,0.0009891848,0.0006175443],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004744934,"about_ca_system_score_gemma":0.0003059031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004854769,"about_ca_topic_score_gemma":0.000575594,"domain_scores_codex":[0.9997713,0.0000293477,0.0000405783,0.00004758044,0.00008379316,0.00002750868],"domain_scores_gemma":[0.9998677,0.00002448968,0.00003009158,0.00002745883,0.00002334175,0.00002693746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001548141,0.000007026132,0.0000687564,0.00002794113,0.000004332111,0.0000440307,0.00001239324,0.00003566895,0.998364,0.0001449288,0.00003597045,0.001239512],"study_design_scores_gemma":[0.00001234652,0.0001127485,0.001692893,0.000009570716,0.00002728235,0.0004362596,0.00001865249,0.001109386,0.9875256,0.00009865332,0.008950113,0.000006499983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8899487,0.00816157,0.09228234,0.000254031,0.0002090036,0.0004681819,0.003492882,0.0004613782,0.004721904],"genre_scores_gemma":[0.9074498,0.004829206,0.07320551,0.0001153522,0.00004549582,0.0001678129,0.006969685,0.0001447709,0.007072245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007234942,"threshold_uncertainty_score":0.003442764,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007942390229472882,"score_gpt":0.2370911750307405,"score_spread":0.2291487848012677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}