{"id":"W2888639317","doi":"10.1172/jci.insight.122204","title":"Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma","year":2018,"lang":"en","type":"article","venue":"JCI Insight","topic":"Head and Neck Cancer Studies","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Health Research Council of New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery; Cancer Research Trust New Zealand; Cancer Society of New Zealand; Halozyme; University of Auckland; Novocure; Genentech; Institute of Environmental Science and Research; Celgene; AstraZeneca; Pfizer","keywords":"Human papillomavirus; Head and neck squamous-cell carcinoma; Head and neck; Basal cell; Oncology; Medicine; Internal medicine; Cancer research; Head and neck cancer; Cancer; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004179486,0.0001447644,0.0003506678,0.00003917585,0.0002464437,0.000006536782,0.00004147795,0.00004751906,0.0000408329],"category_scores_gemma":[0.00002372885,0.00008031627,0.00008353307,0.00008092804,0.0002525268,0.00002826315,0.00001867615,0.00003900134,0.000007752575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007347418,"about_ca_system_score_gemma":0.00004706832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006161827,"about_ca_topic_score_gemma":0.0007996196,"domain_scores_codex":[0.9992896,0.00001754908,0.00019124,0.0002002109,0.0001109908,0.0001904357],"domain_scores_gemma":[0.9992937,0.0002079199,0.00006462741,0.0002426076,0.0001238752,0.00006729169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006339285,0.006457902,0.4031784,0.001499862,0.001011184,0.0001353424,0.2200081,0.000001075223,0.2116766,0.004596923,0.04649989,0.09859543],"study_design_scores_gemma":[0.01079264,0.02730961,0.4090066,0.00007752151,0.0003987969,0.000008447408,0.001186019,0.00007121304,0.3374677,0.0003420398,0.2131205,0.0002189209],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9744776,0.004950125,0.000007939178,0.0005770542,0.0001433223,0.0007093072,0.00002037123,0.00001823327,0.01909604],"genre_scores_gemma":[0.9961626,0.000297449,0.0001864815,0.0002903683,0.0004273935,0.0001075017,0.000003573541,0.00001742714,0.002507213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.218822,"threshold_uncertainty_score":0.3275203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04744462273270051,"score_gpt":0.3223991180531172,"score_spread":0.2749544953204167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}