{"id":"W2888672179","doi":"10.1016/j.exphem.2018.06.102","title":"Dominant-Negative GFI1B Mutations are Causal in Rare Inherited Platelet Disorders and Cause Defects in Stress Thrombopoiesis","year":2018,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Thrombopoiesis; Biology; Zinc finger; Thrombopoietin; Megakaryocyte; Haematopoiesis; Platelet; Myeloproliferative Disorders; Platelet disorder; Cancer research; Molecular biology; Genetics; Gene; Stem cell; Transcription factor; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002592225,0.001275273,0.0004601262,0.001273208,0.0004176051,0.0004059577,0.0005183899,0.001242094,0.003933716],"category_scores_gemma":[0.001418115,0.0001745651,0.0003799175,0.0007735582,0.0008608272,0.0002141137,0.0004044612,0.0005453855,0.0005250886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002822541,"about_ca_system_score_gemma":0.0002624334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009656785,"about_ca_topic_score_gemma":0.000926508,"domain_scores_codex":[0.9997032,0.00005350688,0.00003750353,0.00007009936,0.00009232912,0.00004326001],"domain_scores_gemma":[0.9994204,0.0002064732,0.0002063712,0.00003061866,0.00003117606,0.0001049314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003525971,0.0002426916,0.1496654,0.0004799843,0.0005543751,0.2482733,0.0008145473,0.0006293749,0.5287217,0.006398466,0.008043688,0.0526505],"study_design_scores_gemma":[0.0005967073,0.0005378649,0.2501355,0.000279718,0.0009510078,0.6012077,0.0004604551,0.002694093,0.1128735,0.004115463,0.02606285,0.0000850894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842733,0.004888442,0.002039287,0.001000001,0.0001941387,0.00002976282,0.001396676,0.0001690861,0.006009243],"genre_scores_gemma":[0.9966406,0.0005934719,0.001419398,0.0001625104,0.00009667059,0.00001039554,0.0003563122,0.00003578116,0.0006848052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003933716,"threshold_uncertainty_score":0.01315963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01667959351589406,"score_gpt":0.3121739986216836,"score_spread":0.2954944051057896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}