{"id":"W2888674680","doi":"10.1016/j.celrep.2018.07.061","title":"PAK2 Haploinsufficiency Results in Synaptic Cytoskeleton Impairment and Autism-Related Behavior","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Major State Basic Research Development Program of China; State Key Laboratory of Integrated Pest Management; National Health and Family Planning Commission of the People's Republic of China; University of Kansas; National Natural Science Foundation of China; University of South Carolina","keywords":"Haploinsufficiency; Autism; Neuroscience; Biology; Cell biology; Medicine; Genetics; Psychiatry; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000672814,0.0002173933,0.0002354678,0.0002859682,0.0002161522,0.0000786823,0.0002002263,0.0001371167,0.0001559864],"category_scores_gemma":[0.0004051476,0.0002056611,0.00005042405,0.0006931978,0.0004770927,0.000173353,0.0002707753,0.0003481634,0.0001373612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001350898,"about_ca_system_score_gemma":0.0001659043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002573046,"about_ca_topic_score_gemma":0.00007277223,"domain_scores_codex":[0.9967963,0.0001414924,0.0007489158,0.001025898,0.0005670739,0.0007202819],"domain_scores_gemma":[0.9987166,0.0001086916,0.0002576453,0.000699363,0.00001314128,0.0002045928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002939927,0.004820771,0.05869606,0.0001402217,0.00001129209,0.03365279,0.007457456,0.00004237096,0.8795918,0.005120417,0.001001586,0.009171209],"study_design_scores_gemma":[0.003195888,0.00347193,0.5387857,0.0001589485,0.00005051428,0.003827084,0.0001874431,0.00341333,0.4314383,0.01015822,0.004087996,0.00122471],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796492,0.0001206329,0.00001578642,0.0009396312,0.0003090014,0.0007929822,0.000005886447,0.0001451975,0.01802165],"genre_scores_gemma":[0.997759,0.00007436474,0.00005066411,0.00006501998,0.00001636491,0.00005960004,0.000003396897,0.00003480604,0.001936805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4800896,"threshold_uncertainty_score":0.8386617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01859150736917312,"score_gpt":0.282505129623274,"score_spread":0.2639136222541009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}