{"id":"W2888693079","doi":"10.1016/j.bpj.2018.08.020","title":"Characterization of CTLA4 Trafficking and Implications for Its Function","year":2018,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Human Frontier Science Program; Wellcome Trust","keywords":"CD80; Context (archaeology); In silico; Cell biology; Endocytosis; Internalization; CD86; Regulator; Immune system; Function (biology); Biology; Computational biology; T cell; Receptor; Genetics; In vitro; Cytotoxic T cell; Gene; CD40","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003080713,0.0003331244,0.000170646,0.0003439035,0.0004813684,0.0007471567,0.0005146349,0.0004944298,0.001806439],"category_scores_gemma":[0.0003964828,0.0001236122,0.0004599002,0.0003279734,0.0003574278,0.0005722095,0.0002784156,0.00101593,0.0009093176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009304694,"about_ca_system_score_gemma":0.0005214961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001708492,"about_ca_topic_score_gemma":0.0006743274,"domain_scores_codex":[0.9998865,0.00002670052,0.00001271919,0.00002249035,0.00001481562,0.00003671871],"domain_scores_gemma":[0.9998214,0.00004595983,0.00002238489,0.00003213299,0.00004747712,0.00003071352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002588149,0.00004675236,0.0006884173,0.00002713297,0.000006862509,0.0001196096,0.00002999259,0.0001742792,0.9956989,0.0008119982,0.00006858265,0.00206877],"study_design_scores_gemma":[0.00003483302,0.0001481458,0.006071064,0.00001489086,0.00003039118,0.0007352828,0.0002050555,0.005656736,0.9787294,0.0008886034,0.00747541,0.0000103252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896837,0.001274408,0.005468746,0.0006100722,0.00004819222,0.0000244182,0.0004945602,0.00004269317,0.002353253],"genre_scores_gemma":[0.9900362,0.0006804655,0.003777404,0.000171499,0.00001673799,0.00003698048,0.001373244,0.0000343529,0.003873032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001806439,"threshold_uncertainty_score":0.00675106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01770227054808187,"score_gpt":0.243598603912984,"score_spread":0.2258963333649021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}