{"id":"W2888693079","doi":"10.1016/j.bpj.2018.08.020","title":"Characterization of CTLA4 Trafficking and Implications for Its Function","year":2018,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"Biotechnology and Biological Sciences Research Council; Medical Research Council; Human Frontier Science Program; Wellcome Trust","keywords":"CD80; Context (archaeology); In silico; Cell biology; Endocytosis; Internalization; CD86; Regulator; Immune system; Function (biology); Biology; Computational biology; T cell; Receptor; Genetics; In vitro; Cytotoxic T cell; Gene; CD40","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007242933,0.00007539227,0.0001410489,0.00005537017,0.0002435958,0.00001287171,0.00007554713,0.0001132351,0.00005824223],"category_scores_gemma":[0.00002095586,0.00006181579,0.00005852159,0.00006835371,0.000175984,0.00009321824,0.00002130051,0.0001161329,0.00004189065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009275879,"about_ca_system_score_gemma":0.00002152734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.822067e-7,"about_ca_topic_score_gemma":5.4742e-7,"domain_scores_codex":[0.9994841,0.00004120268,0.0001938013,0.0001146594,0.00001189172,0.0001543388],"domain_scores_gemma":[0.9995341,0.00004304847,0.0001529402,0.00007361561,0.0001804991,0.0000158151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001421935,0.0001015743,0.0001115283,0.000006399277,0.00006231388,6.652421e-8,0.00009211758,6.370661e-8,0.9849724,0.00263527,0.000126897,0.01174923],"study_design_scores_gemma":[0.000747558,0.0006569236,0.01768002,0.000013034,0.00005281659,0.0000771852,0.0000225715,0.00001066743,0.9681169,0.000204546,0.01234167,0.00007612313],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928797,0.00008953976,0.005772722,0.000469761,0.0005743313,0.0001048906,0.00002196719,0.00001735868,0.0000697648],"genre_scores_gemma":[0.9992059,0.00004598966,0.00004233339,0.00006715647,0.0002745675,0.000006626927,0.00004153288,0.000007553085,0.0003083118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01756849,"threshold_uncertainty_score":0.2520775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01770227054808187,"score_gpt":0.243598603912984,"score_spread":0.2258963333649021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}