{"id":"W2888746889","doi":"10.1242/dmm.035576","title":"Zoledronic acid prevents pagetic-like lesions and accelerated bone loss in the p62P394L mouse model of Paget's disease","year":2018,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Bone health and treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Novartis Pharmaceuticals UK Limited; Medical Research Council Canada; University of Oxford; Versus Arthritis; Arthritis Research UK; European Calcified Tissue Society; Amgen","keywords":"Paget's disease of bone; Zoledronic acid; Osteoclast; RANKL; Internal medicine; Lesion; Ageing; Endocrinology; Bone remodeling; Bone disease; Medicine; Pathology; Disease; Osteoporosis; Activator (genetics)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004404305,0.001081315,0.001329697,0.001728776,0.0004448078,0.0005157057,0.0006084687,0.001718993,0.002129974],"category_scores_gemma":[0.0002525671,0.0006180185,0.0008401237,0.0004967921,0.0007037676,0.0005337862,0.000429444,0.001707788,0.0007792179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005400581,"about_ca_system_score_gemma":0.0003969687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001016714,"about_ca_topic_score_gemma":0.001713667,"domain_scores_codex":[0.9992843,0.0001071955,0.0001017494,0.0001219913,0.0002168363,0.0001679366],"domain_scores_gemma":[0.9992872,0.00004490783,0.0002753773,0.00006046006,0.00005611718,0.0002759767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001522661,0.0004752149,0.0003188285,0.00008539942,0.00001662795,0.0001972379,0.00003340989,0.0001125262,0.9956527,0.0001333332,0.0001280676,0.00132396],"study_design_scores_gemma":[0.0008057342,0.0106766,0.0148543,0.00005235834,0.0001212288,0.001496972,0.0001433267,0.002752476,0.9641019,0.0002805291,0.0046651,0.0000493677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923986,0.002079863,0.002176473,0.0002355037,0.0001217096,0.0001347595,0.0013361,0.0004886303,0.001028392],"genre_scores_gemma":[0.9867775,0.001235197,0.002921201,0.0001688645,0.00004565212,0.0002745323,0.001263268,0.00009632441,0.007217541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002129974,"threshold_uncertainty_score":0.007125437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0508216049177624,"score_gpt":0.3023838909366546,"score_spread":0.2515622860188922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}