{"id":"W2888767924","doi":"10.1038/s41380-018-0226-y","title":"Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments","year":2018,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Natural Sciences and Engineering Research Council of Canada; Centre National de la Recherche Scientifique; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Neuroscience; Dopamine; Prefrontal cortex; Monoamine neurotransmitter; Psychology; Synapse; Homeostasis; Biology; Cognition; Endocrinology; Serotonin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001145263,0.0003132459,0.0001933158,0.0002909862,0.0002127273,0.0002255335,0.0001881771,0.0001851832,0.0004517423],"category_scores_gemma":[0.0001309989,0.0001307576,0.0001726506,0.0001127287,0.0002697429,0.00009971832,0.0002718781,0.0003954306,0.0001501704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002788066,"about_ca_system_score_gemma":0.0004775713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002095577,"about_ca_topic_score_gemma":0.003281576,"domain_scores_codex":[0.9998784,0.00001110905,0.00001064697,0.00002845107,0.00004344286,0.00002800236],"domain_scores_gemma":[0.9998597,0.000007508063,0.00006076258,0.00001562965,0.00002129752,0.00003506491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001346701,0.00002854346,0.0019311,0.00002611374,0.00001118386,0.0005506072,0.00002921957,0.00006950527,0.9940328,0.0001734742,0.00005275885,0.002960184],"study_design_scores_gemma":[0.00002519147,0.0003269965,0.06120564,0.00001554111,0.00006678568,0.005235461,0.0002448087,0.001160529,0.9285974,0.0006397923,0.00247052,0.00001131632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937967,0.001537098,0.003250141,0.0001030541,0.00002429984,0.00001190903,0.000227148,0.00008133252,0.0009682696],"genre_scores_gemma":[0.9967411,0.0009293682,0.001380189,0.00002878179,0.000005375012,0.00001100891,0.0001301099,0.0000113214,0.0007627188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002095577,"threshold_uncertainty_score":0.004166782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01521355827504099,"score_gpt":0.3126009546725455,"score_spread":0.2973873963975045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}