{"id":"W2888774667","doi":"10.1038/s41594-018-0123-8","title":"Reconstitution of anaphase DNA bridge recognition and disjunction","year":2018,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Genetics; National Cancer Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Fonds National de la Recherche Luxembourg; Danmarks Grundforskningsfond; Agence Nationale de la Recherche; European Commission","keywords":"Sister chromatids; Anaphase; Chromosome segregation; Biology; Centromere; DNA; Genetics; Chromosomal fragile site; Nondisjunction; DNA replication; Cell biology; Computational biology; Chromosome; Aneuploidy; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005273492,0.0006705348,0.0004685696,0.0004548246,0.000698464,0.001293118,0.001378704,0.001117011,0.005071753],"category_scores_gemma":[0.000513968,0.000762501,0.0005311106,0.0005006538,0.0005814468,0.0008035483,0.001104594,0.003075668,0.002675545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001410277,"about_ca_system_score_gemma":0.000741212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002752037,"about_ca_topic_score_gemma":0.003475246,"domain_scores_codex":[0.9993138,0.00007633297,0.00007904769,0.0001899336,0.0001967149,0.0001441157],"domain_scores_gemma":[0.9994786,0.000129364,0.00009808191,0.0001468882,0.00003709299,0.0001100512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002012198,0.0001347971,0.0002594028,0.00006235675,0.00001415063,0.00006749281,0.00005224934,0.0002065136,0.9949464,0.001541703,0.000326673,0.002187016],"study_design_scores_gemma":[0.00003904415,0.00002941459,0.001002059,0.000006393105,0.000008279765,0.00007523646,0.00002805441,0.001357199,0.9906149,0.0001336827,0.006697215,0.00000847934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9585024,0.00134272,0.02457611,0.0009612573,0.0003646256,0.0002826759,0.003851952,0.001440099,0.00867822],"genre_scores_gemma":[0.9667379,0.000639023,0.00990934,0.0001906514,0.00002932467,0.0001242679,0.00509946,0.0004157371,0.01685431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005071753,"threshold_uncertainty_score":0.0169667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008476114485062382,"score_gpt":0.2842414482754599,"score_spread":0.2757653337903975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}