{"id":"W2888810646","doi":"10.1016/j.celrep.2018.07.086","title":"The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; National Institutes of Health; Terry Fox Research Institute; Dalhousie Medical Research Foundation; Beatrice Hunter Cancer Research Institute","keywords":"NAD+ kinase; Nicotinamide phosphoribosyltransferase; Serine; Nucleotide salvage; Biosynthesis; Cofactor; Nicotinamide; Nicotinamide adenine dinucleotide; Biology; Enzyme; Dehydrogenase; Biochemistry; Cancer research; Chemistry; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000071465,0.0001503006,0.0001531243,0.00007800406,0.000129017,0.0002582464,0.0001637297,0.0001516063,0.001146615],"category_scores_gemma":[0.00007603661,0.00006132494,0.0001154712,0.00005703211,0.0001913149,0.0001635232,0.0001791793,0.0002664725,0.0003609152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002582914,"about_ca_system_score_gemma":0.0002036502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006319489,"about_ca_topic_score_gemma":0.0009551725,"domain_scores_codex":[0.9999512,0.000005456312,0.000004100189,0.00001126524,0.00001524814,0.00001270225],"domain_scores_gemma":[0.999936,0.000008723612,0.00001335952,0.00001183412,0.000009621944,0.00002044952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007365864,0.000006404729,0.0003724856,0.00002040661,0.000002117408,0.00003688765,0.00000522251,0.00002571232,0.9981824,0.0001642017,0.00004503161,0.001065427],"study_design_scores_gemma":[0.000005138074,0.00005829638,0.003266774,0.000001993378,0.00000287266,0.0002205368,0.00001482969,0.00033442,0.9934289,0.00007410857,0.002590578,0.000001666023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900946,0.001291796,0.004724641,0.0002654742,0.00003879869,0.00001636646,0.0005328762,0.0001307148,0.002904848],"genre_scores_gemma":[0.9966366,0.0003495275,0.001514255,0.00003539685,0.000004938964,0.00000571517,0.0003708877,0.000009213113,0.001073303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001146615,"threshold_uncertainty_score":0.003835797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007485476246687702,"score_gpt":0.2201873608246311,"score_spread":0.2127018845779434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}