{"id":"W2888848434","doi":"10.3389/fncir.2018.00064","title":"Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio","year":2018,"lang":"en","type":"article","venue":"Frontiers in Neural Circuits","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Parkinsonfonden; Uppsala Universitet; Åhlén-stiftelsen; Vetenskapsrådet; Stiftelsen Olle Engkvist Byggmästare; Karolinska Institutet; Bertil Hållstens Forskningsstiftelse; Hjärnfonden; Knut och Alice Wallenbergs Stiftelse; Linköpings Universitet; McGill University","keywords":"Glutamatergic; Medium spiny neuron; AMPA receptor; Neurotransmission; Neuroscience; Nucleus accumbens; Glutamate receptor; Dopamine; Synaptic plasticity; NMDA receptor; Excitatory postsynaptic potential; Amphetamine; Ventral tegmental area; Biology; Dopaminergic; Striatum; Receptor; Inhibitory postsynaptic potential; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000770282,0.0003443261,0.0002602566,0.0001340224,0.0001047366,0.0002694843,0.000322316,0.0004086586,0.001021098],"category_scores_gemma":[0.00008071325,0.0001261115,0.0002434345,0.00008354558,0.0002229978,0.0002275288,0.0001620551,0.0005492886,0.0002254716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002517985,"about_ca_system_score_gemma":0.0001564538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006311436,"about_ca_topic_score_gemma":0.001571226,"domain_scores_codex":[0.9999007,0.000005935748,0.000009753895,0.0000382623,0.00002364544,0.00002173415],"domain_scores_gemma":[0.9999155,0.00000947197,0.00003086806,0.000009352783,0.000009703992,0.00002511657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002304205,0.000008238933,0.0001378888,0.00001766025,0.000002112161,0.00002923458,0.000006332656,0.00001860785,0.9992304,0.0000267849,0.000008408911,0.0004913561],"study_design_scores_gemma":[0.00000849838,0.0002465105,0.004541699,0.000004329056,0.00001588705,0.0002988839,0.0000189465,0.0005500319,0.9931926,0.00002761644,0.001091813,0.000003153561],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933414,0.0006442455,0.004762307,0.00008355156,0.00001814216,0.00002190577,0.0003392304,0.0001150525,0.00067409],"genre_scores_gemma":[0.9913126,0.0005717495,0.004883649,0.00008103952,0.000006535452,0.00004579523,0.0004104421,0.00004406228,0.002644213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001021098,"threshold_uncertainty_score":0.003415883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01989726126882132,"score_gpt":0.2958824703163082,"score_spread":0.2759852090474869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}