{"id":"W2888848434","doi":"10.3389/fncir.2018.00064","title":"Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio","year":2018,"lang":"en","type":"article","venue":"Frontiers in Neural Circuits","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Parkinsonfonden; Uppsala Universitet; Åhlén-stiftelsen; Vetenskapsrådet; Stiftelsen Olle Engkvist Byggmästare; Karolinska Institutet; Bertil Hållstens Forskningsstiftelse; Hjärnfonden; Knut och Alice Wallenbergs Stiftelse; Linköpings Universitet; McGill University","keywords":"Glutamatergic; Medium spiny neuron; AMPA receptor; Neurotransmission; Neuroscience; Nucleus accumbens; Glutamate receptor; Dopamine; Synaptic plasticity; NMDA receptor; Excitatory postsynaptic potential; Amphetamine; Ventral tegmental area; Biology; Dopaminergic; Striatum; Receptor; Inhibitory postsynaptic potential; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007007557,0.000405675,0.000546662,0.000707417,0.0003696897,0.0002050186,0.0005366816,0.0001610811,0.00002735874],"category_scores_gemma":[0.002605933,0.0003953267,0.0000672596,0.001028691,0.0005837514,0.0008059707,0.0001215714,0.0006527647,0.000005147588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009589072,"about_ca_system_score_gemma":0.0001222255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001038482,"about_ca_topic_score_gemma":0.00003637994,"domain_scores_codex":[0.9953848,0.001120081,0.0007071524,0.001220418,0.0004557034,0.001111908],"domain_scores_gemma":[0.998358,0.0009263835,0.0001619712,0.0001957455,0.00005112079,0.0003067458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007951044,0.0002302584,0.01895504,0.00009800258,0.000002235574,0.0002849591,0.0002533325,0.0002692788,0.9756108,0.000006245594,0.0007730253,0.002721742],"study_design_scores_gemma":[0.003706455,0.0006229393,0.01107555,0.0001613192,0.00002160485,0.0001403458,0.0001915371,0.332955,0.6500865,0.0001596931,0.0003565445,0.000522461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963664,0.0004287912,0.001017445,0.0002432005,0.0005850266,0.001125118,0.0001310248,0.00008055133,0.00002238352],"genre_scores_gemma":[0.9985172,0.0003196197,0.00006161611,0.000774546,0.0000912514,0.0001210777,0.00001196587,0.00005357917,0.00004917018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3326857,"threshold_uncertainty_score":0.9998499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01989726126882132,"score_gpt":0.2958824703163082,"score_spread":0.2759852090474869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}