{"id":"W2888859121","doi":"10.1016/j.omtn.2018.08.018","title":"Protecting Pax6 3′ UTR from MicroRNA-7 Partially Restores PAX6 in Islets from an Aniridia Mouse Model","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; National Science Council; Alexander and Margaret Stewart Trust","keywords":"PAX6; Aniridia; Haploinsufficiency; Biology; microRNA; Cancer research; Pancreatic islets; Cell biology; Islet; Endocrinology; Genetics; Gene; Phenotype; Diabetes mellitus; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002758135,0.0004024008,0.0002929915,0.00008858936,0.0001691031,0.0001007588,0.0005427155,0.0004053154,0.0001018227],"category_scores_gemma":[0.00007699896,0.0004211237,0.0001590625,0.0001508186,0.0001984924,0.0000257875,0.0001532335,0.0002315334,0.00004501491],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006680369,"about_ca_system_score_gemma":0.0001417063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005638162,"about_ca_topic_score_gemma":0.0002818851,"domain_scores_codex":[0.9975022,0.0003083542,0.0004454961,0.0009600006,0.0002803646,0.0005035949],"domain_scores_gemma":[0.9983163,0.00001110554,0.0001907082,0.001152838,0.0001407446,0.0001882902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005739047,0.0001908046,0.002345851,0.000004304239,0.0001086364,0.00001767535,0.0004489159,0.0004480031,0.9916626,0.000015971,0.0002159673,0.003967344],"study_design_scores_gemma":[0.001588692,0.0003159377,0.005580302,0.00002977566,0.00002014423,0.000002044608,0.00005438373,0.004778012,0.9828135,0.0009702135,0.003338189,0.0005087704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864761,0.001093889,0.01117033,0.000194102,0.0001317082,0.0006245476,0.0001348546,0.00007222079,0.0001022871],"genre_scores_gemma":[0.9905792,0.0000945881,0.006991132,0.001072988,0.0004800761,0.0000762365,0.0005044498,0.0001407111,0.00006061468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008849087,"threshold_uncertainty_score":0.999824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01423286193013028,"score_gpt":0.262304173434122,"score_spread":0.2480713115039918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}