{"id":"W2888864611","doi":"10.1016/j.tet.2018.08.034","title":"Enantioselective palladium-catalyzed addition of malonates to 3,3-difluoropropenes","year":2018,"lang":"en","type":"article","venue":"Tetrahedron","topic":"Fluorine in Organic Chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"PROTEO; Université Laval","funders":"Fonds de recherche du Québec – Nature et technologies; Comprehensive Cardiovascular Center; Natural Sciences and Engineering Research Council of Canada; Centre in Green Chemistry and Catalysis","keywords":"Chemistry; Enantioselective synthesis; Malonate; Palladium; Alkene; Reactivity (psychology); Catalysis; Alkyl; Stereochemistry; Medicinal chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003293401,0.0002084022,0.0002659179,0.00009890382,0.0001307863,0.000009957916,0.0003456716,0.0002489418,0.01209746],"category_scores_gemma":[0.0002771264,0.000199891,0.00007347439,0.0003985435,0.0002823908,0.00009357752,0.0001135488,0.0003246306,0.0009988889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001050898,"about_ca_system_score_gemma":0.00009012086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005520712,"about_ca_topic_score_gemma":0.00003503932,"domain_scores_codex":[0.9986396,0.00009840883,0.0003415352,0.0003561589,0.0001739666,0.0003902661],"domain_scores_gemma":[0.9989363,0.0002144597,0.0001231282,0.0002770756,0.0002608641,0.0001881673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003532871,0.0002117585,0.003565073,0.00005670276,0.0001156695,0.000009885346,0.0005024938,0.000006322624,0.9621927,0.0003059672,0.02044025,0.0122399],"study_design_scores_gemma":[0.0007552741,0.0002561264,0.005706041,0.00002282808,0.00006496022,0.00002655387,0.00005915826,0.00008167588,0.9366606,0.0003640181,0.05578374,0.0002189524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831379,0.0001593013,0.00008926212,0.0004976174,0.0007581533,0.0003290091,0.0001257546,0.0001385507,0.01476446],"genre_scores_gemma":[0.9962806,0.00002865458,0.0006248765,0.0003779318,0.0006243686,0.00005164286,0.00005448929,0.0000350786,0.00192238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0353435,"threshold_uncertainty_score":0.9997789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07111375850964849,"score_gpt":0.4122948495117901,"score_spread":0.3411810910021416,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}