{"id":"W2888877405","doi":"10.1161/circgen.118.002300","title":"When to Offer Predictive Genetic Testing to Children at Risk of an Inherited Arrhythmia or Cardiomyopathy","year":2018,"lang":"en","type":"article","venue":"Circulation Genomic and Precision Medicine","topic":"Cardiovascular Effects of Exercise","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Heart Rhythm Society","keywords":"Genetic testing; Predictive testing; Medicine; Personalized medicine; Medical genetics; Precision medicine; Family medicine; Internal medicine; Bioinformatics; Genetics; Biology; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001087875,0.0002533838,0.0007702328,0.0004014962,0.0001513786,0.00001123707,0.0001145337,0.0001361954,0.0002164018],"category_scores_gemma":[0.002133087,0.0001921268,0.0001039045,0.0004844476,0.0001677078,0.00006789487,0.0001646849,0.0001365919,0.00005686218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001629905,"about_ca_system_score_gemma":0.00007660701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000242025,"about_ca_topic_score_gemma":0.00001989511,"domain_scores_codex":[0.9977664,0.0002182327,0.0005609847,0.0006408402,0.0005532211,0.0002602899],"domain_scores_gemma":[0.9976829,0.0002987203,0.0001664962,0.000796908,0.000491445,0.0005635715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.004447488,0.00004371999,0.3557789,0.0000851164,0.0004354373,0.00004839271,0.005908313,0.002485672,0.1027271,0.000001418384,0.001274734,0.5267637],"study_design_scores_gemma":[0.002907085,0.00251999,0.9868422,0.0004770466,0.0006793946,0.0005338782,0.00008377033,0.004052672,0.0007670934,0.00008481954,0.0008556235,0.0001963905],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782761,0.0007844151,0.01801674,0.0001949975,0.0002490904,0.002015653,0.0000364529,0.00006515608,0.0003614123],"genre_scores_gemma":[0.9849277,0.00004643203,0.01264153,0.0003265626,0.001810446,0.00003643564,0.00004908308,0.00005141537,0.0001104061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6310633,"threshold_uncertainty_score":0.7834703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01844602497096349,"score_gpt":0.2664643415137342,"score_spread":0.2480183165427707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}