{"id":"W2888879580","doi":"10.1371/journal.pone.0202778","title":"c-Myb regulates transcriptional activation of miR-143/145 in vascular smooth muscle cells","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Toronto General Hospital; University of Toronto; Ted Rogers Centre for Heart Research; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"Vascular smooth muscle; Molecular biology; Biology; MYB; Chromatin immunoprecipitation; Untranslated region; Reporter gene; Transcription factor; Cell biology; Gene expression; Messenger RNA; Promoter; Gene; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001788674,0.000260835,0.0001869684,0.0002232584,0.0002430075,0.0003290197,0.0001314399,0.0002121544,0.001760487],"category_scores_gemma":[0.0001390627,0.0001873064,0.0002819166,0.00008836981,0.0002422765,0.0001281175,0.0002848165,0.0004990855,0.0008139454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002856838,"about_ca_system_score_gemma":0.0001789836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004070202,"about_ca_topic_score_gemma":0.00058477,"domain_scores_codex":[0.9998369,0.0000207544,0.0000111282,0.00004586063,0.0000524161,0.00003287102],"domain_scores_gemma":[0.9998552,0.00002471579,0.00004438395,0.00001098494,0.00002354089,0.00004116181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004744725,0.000009597445,0.0003161002,0.00001774244,0.000002121842,0.0000245463,0.00001063242,0.00001046946,0.9990665,0.00006275593,0.00002849417,0.0004036033],"study_design_scores_gemma":[0.00003681687,0.000192156,0.05852302,0.00002706883,0.00002070664,0.0004198145,0.00005452899,0.00158876,0.9357473,0.0001075502,0.003275628,0.000006495273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916009,0.00248813,0.003081845,0.00008465126,0.00003929559,0.00002287418,0.0004706354,0.00005641958,0.002155265],"genre_scores_gemma":[0.9933299,0.0005791851,0.002974563,0.00008639849,0.00001605488,0.000046716,0.001052712,0.00002418077,0.001890113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001760487,"threshold_uncertainty_score":0.005889416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01891335603762648,"score_gpt":0.213700088056734,"score_spread":0.1947867320191075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}