{"id":"W2888882306","doi":"10.1002/pbc.27389","title":"Sustained complete response of recurrent glioblastoma to combined checkpoint inhibition in a young patient with constitutional mismatch repair deficiency","year":2018,"lang":"en","type":"letter","venue":"Pediatric Blood & Cancer","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; McGill University; McGill University Health Centre; Montreal Children's Hospital; Hospital for Sick Children; Université Laval","funders":"","keywords":"Medicine; Glioblastoma; Oncology; Complete response; Internal medicine; Cancer research; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003213091,0.0003935304,0.0007753898,0.0004263552,0.0009925143,0.0006426479,0.0005909278,0.004863181,0.001306275],"category_scores_gemma":[0.003086587,0.0002723038,0.0005930716,0.0003504393,0.000549436,0.0007149445,0.0004357587,0.003348983,0.0006139111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001413413,"about_ca_system_score_gemma":0.0007525772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001819573,"about_ca_topic_score_gemma":0.003363269,"domain_scores_codex":[0.9996853,0.00007141879,0.00003450223,0.00005574309,0.00005040082,0.0001025509],"domain_scores_gemma":[0.9990416,0.0004220168,0.00009827332,0.00005279485,0.00008479271,0.0003005082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0002013624,0.00005143115,0.008680071,0.00004190113,0.00001944082,0.9670963,0.0001480225,0.0002321672,0.00159008,0.0008119284,0.01485771,0.006269557],"study_design_scores_gemma":[0.0001039399,0.0003720595,0.01211814,0.00007769847,0.00004583187,0.9662561,0.0002983004,0.001736458,0.001480657,0.00184409,0.01562949,0.00003728767],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6461352,0.00992048,0.003186665,0.2926916,0.009580243,0.0001710845,0.0006352716,0.0003337571,0.03734583],"genre_scores_gemma":[0.9463439,0.002847662,0.001409838,0.03510343,0.007212426,0.00004671009,0.0001877807,0.00005265056,0.006795544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004863181,"threshold_uncertainty_score":0.0102551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273300884123479,"score_gpt":0.2512128047260025,"score_spread":0.2384797958847677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}