{"id":"W2888882306","doi":"10.1002/pbc.27389","title":"Sustained complete response of recurrent glioblastoma to combined checkpoint inhibition in a young patient with constitutional mismatch repair deficiency","year":2018,"lang":"en","type":"letter","venue":"Pediatric Blood & Cancer","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; McGill University; McGill University Health Centre; Montreal Children's Hospital; Hospital for Sick Children; Université Laval","funders":"","keywords":"Medicine; Glioblastoma; Oncology; Complete response; Internal medicine; Cancer research; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004811461,0.000612074,0.001031192,0.0009958101,0.00008600424,0.00001945887,0.0001626298,0.0005543733,0.0004339359],"category_scores_gemma":[0.0004106593,0.0004919054,0.0002555287,0.001526776,0.0005144896,0.00005144868,0.0002176381,0.001166116,0.00002247613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009819235,"about_ca_system_score_gemma":0.002896569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003766979,"about_ca_topic_score_gemma":0.000400711,"domain_scores_codex":[0.9953568,0.0002612176,0.001160022,0.001007411,0.001423069,0.0007914691],"domain_scores_gemma":[0.9971814,0.0002622647,0.0006191238,0.0006634316,0.001060163,0.000213679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.06562901,0.001792443,0.06222791,0.006316316,0.0004349227,0.002982186,0.003433014,0.000174072,0.002302677,0.00003231189,0.8544202,0.00025495],"study_design_scores_gemma":[0.1149024,0.3007738,0.210743,0.02385844,0.02209437,0.008349966,0.002529777,0.0008749327,0.06081485,0.0007825004,0.2394288,0.01484711],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517452,0.001150312,0.0000586367,0.04222114,0.001138903,0.00256653,0.0006046947,0.0001225451,0.000392115],"genre_scores_gemma":[0.9673685,0.0001580969,0.001475212,0.02713573,0.002386965,0.0009989908,0.0001631321,0.00009537215,0.0002179634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6149914,"threshold_uncertainty_score":0.9997532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273300884123479,"score_gpt":0.2512128047260025,"score_spread":0.2384797958847677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}