{"id":"W2888889590","doi":"10.1242/dmm.034801","title":"Idebenone and coenzyme Q10 are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases","year":2018,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Aptose Biosciences (Canada); University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ontario Centres of Excellence","keywords":"Coenzyme Q10; Peroxisome; Rosiglitazone; Idebenone; Nonalcoholic fatty liver disease; Peroxisome proliferator-activated receptor; Pharmacology; Receptor; Fatty liver; Steatosis; Agonist; Biology; Partial agonist; Endocrinology; Biochemistry; Internal medicine; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003234445,0.0002789705,0.0002722146,0.00004961615,0.0001302939,0.00002682205,0.0001145869,0.0001085029,0.00001593111],"category_scores_gemma":[0.00001405005,0.0002202852,0.0001150703,0.00005911395,0.0001409783,0.00001565539,0.00006249475,0.00002088976,0.000001385429],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002306027,"about_ca_system_score_gemma":0.000122007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001706456,"about_ca_topic_score_gemma":0.00001382434,"domain_scores_codex":[0.9988077,0.00001472233,0.0001781607,0.0005279306,0.0001768169,0.0002946438],"domain_scores_gemma":[0.9989687,0.000007249615,0.000127784,0.0003430339,0.000212736,0.0003405136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003185313,0.0009321574,0.0002745692,0.00008750329,0.0002865787,0.000008483528,0.00007688603,0.0002997016,0.9929273,0.001031591,0.0001916521,0.0006982806],"study_design_scores_gemma":[0.00269187,0.001788444,0.0003675087,0.00003993303,0.0002624396,0.000006488839,0.00007224258,0.01155384,0.9812797,0.001401943,0.0002074604,0.0003281378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7136141,0.001175924,0.2835266,0.00005020411,0.00007229002,0.0005076458,0.001026538,0.00002079248,0.000005888764],"genre_scores_gemma":[0.9952379,0.0002711844,0.003484108,0.0001120233,0.0002446604,0.0001886372,0.0003181148,0.00005205215,0.00009129864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2816238,"threshold_uncertainty_score":0.8982972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01443996879890817,"score_gpt":0.2300453125484629,"score_spread":0.2156053437495548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}