{"id":"W2888889590","doi":"10.1242/dmm.034801","title":"Idebenone and coenzyme Q10 are novel PPARα/γ ligands, with potential for treatment of fatty liver diseases","year":2018,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Aptose Biosciences (Canada); University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ontario Centres of Excellence","keywords":"Coenzyme Q10; Peroxisome; Rosiglitazone; Idebenone; Nonalcoholic fatty liver disease; Peroxisome proliferator-activated receptor; Pharmacology; Receptor; Fatty liver; Steatosis; Agonist; Biology; Partial agonist; Endocrinology; Biochemistry; Internal medicine; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001687121,0.00034396,0.0001907562,0.000327828,0.0001249119,0.000236204,0.0002275025,0.0002713077,0.004460945],"category_scores_gemma":[0.00007798183,0.0001015635,0.000161596,0.0001341163,0.000186952,0.0002019557,0.0002274796,0.0004760043,0.0009380124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002116168,"about_ca_system_score_gemma":0.0002584452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004329966,"about_ca_topic_score_gemma":0.001235182,"domain_scores_codex":[0.9999591,0.000008829855,0.000002426335,0.000008365155,0.00001434125,0.000006958654],"domain_scores_gemma":[0.9999638,0.000004708434,0.000009440646,0.000001831357,0.000006458008,0.00001380814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001583053,0.0003024598,0.0007179673,0.0006095739,0.00003216059,0.0005468601,0.00003968951,0.0004400781,0.8894666,0.002674639,0.002043378,0.1015436],"study_design_scores_gemma":[0.001087691,0.007017763,0.008836362,0.0001849019,0.0001261607,0.003509317,0.0001197755,0.001034084,0.709621,0.001815377,0.2665817,0.00006595811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.698683,0.2068869,0.02880812,0.00570237,0.002116323,0.00056239,0.002741414,0.0003888845,0.05411064],"genre_scores_gemma":[0.8202806,0.1023165,0.01125595,0.000956792,0.0002237319,0.0002197409,0.001405638,0.00004234661,0.06329866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004460945,"threshold_uncertainty_score":0.01492327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01443996879890817,"score_gpt":0.2300453125484629,"score_spread":0.2156053437495548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}